Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sorcek Ronald J"'
Autor:
Pauls, Eduardo, Shpiro, Natalia, Peggie, Mark, Young, Erick R., Sorcek, Ronald J., Tan, Li, Choi, Hwan Geun, Cohen, Philip
Publikováno v:
In Journal of Biological Chemistry 1 June 2012 287(23):19216-19228
Autor:
Natalia Shpiro, Philip Cohen, Li Tan, Eduardo Pauls, Erick R. R. Young, Mark Peggie, Sorcek Ronald J, Hwangeun G. Choi
Publikováno v:
Journal of Biological Chemistry. 287:19216-19228
Plasmacytoid dendritic cells (pDCs) are characterized by their ability to produce high levels of type 1 interferons in response to ligands that activate TLR7 and TLR9, but the signaling pathways required for IFN production are incompletely understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c034d38b1d9dae6417f6e512644688b4
https://doi.org/10.1074/jbc.m112.345405
https://doi.org/10.1074/jbc.m112.345405
Publikováno v:
Tetrahedron Letters. 34:2259-2262
Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from ( R )-phenylglycinol and ( R )-valinol afforded high diasteriomeric selectivity. Upon oxidative cleavage, the S - primary amine with high ee was obtained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77987fd8fad861d5f7746a9026aa4255
https://doi.org/10.1016/s0040-4039(00)77588-5
https://doi.org/10.1016/s0040-4039(00)77588-5
Autor:
Stephen Jacober, Philip W. Mui, Jerry W. Skiles, Sorcek Ronald J, Miao Clara K, Alan S. Rosenthal, Mcneil Daniel W
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:773-778
The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e0fee2d6358b5027a3474967bc4662
https://doi.org/10.1016/s0960-894x(01)81273-7
https://doi.org/10.1016/s0960-894x(01)81273-7
Autor:
Edward G. McIver, Lorna Plater, Mark Peggie, Jeffrey B. Madwed, Joanne Hough, Philip Cohen, Erick R. R. Young, Kristopher Clark, Sorcek Ronald J
Publikováno v:
The Biochemical journal. 434(1)
Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by inducing NF-κB- and IRF [IFN (interferon) regulatory factor]-dependent gene transcription programmes required for the produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f795c03d0dc96270cd6f723c1bdaefd
https://pubmed.ncbi.nlm.nih.gov/21269273
https://pubmed.ncbi.nlm.nih.gov/21269273
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7433c34ab365a87395177b5ae170c41b
https://doi.org/10.1002/chin.199236064
https://doi.org/10.1002/chin.199236064
Publikováno v:
ChemInform. 24
Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from ( R )-phenylglycinol and ( R )-valinol afforded high diasteriomeric selectivity. Upon oxidative cleavage, the S - primary amine with high ee was obtained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8bce860d4d7af42391cec1a3df5b2b6
https://doi.org/10.1002/chin.199337222
https://doi.org/10.1002/chin.199337222
Autor:
Sorcek Ronald J, Julian Adams, Lazer Edward S, J. M. Watrous, Yvan Guindon, H.‐C. Wong, Carol Ann Homon, Kollol Pal, Jürgen H. Nagel, Mark L. Behnke, A. Shah, Miao Clara K, A. G. Graham, A. Gilman, Denice M. Spero, Peter R. Farina
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade8f0d4a443d8ee74fe9e365953d8c0
https://doi.org/10.1002/chin.199434152
https://doi.org/10.1002/chin.199434152
Autor:
Sorcek Ronald J, L. Churchill, Lazer Edward S, Genus J. Possanza, Charles L. Cywin, Diane Thome, A. G. Graham
Publikováno v:
ChemInform. 29
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f54a6a730de269c3f6fc944343649810
https://doi.org/10.1002/chin.199838165
https://doi.org/10.1002/chin.199838165
Publikováno v:
Organic Preparations and Procedures International. 24:87-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d3d2f5ace826ec64f84436db39aed8e
https://doi.org/10.1080/00304949209356710
https://doi.org/10.1080/00304949209356710