Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents

Autor: Linciano, Pasquale, Sorbi, Claudia, Rossino, Giacomo, Rossi, Daniela, Marsala, Andrea, Denora, Nunzio, Bedeschi, Martina, Marino, Noemi, Miserocchi, Giacomo, Dondio, Giulio, Peviani, Marco, Tesei, Anna, Collina, Simona, Franchini, Silvia

Publikováno v: In European Journal of Medicinal Chemistry 5 March 2023 249

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting.

Autor: Sorbi, Claudia¹ (AUTHOR), Belluti, Silvia¹ (AUTHOR), Atene, Claudio Giacinto² (AUTHOR), Marocchi, Federica³ (AUTHOR), Linciano, Pasquale⁴ (AUTHOR), Roy, Neena⁵ (AUTHOR), Paradiso, Elia⁵ (AUTHOR), Casarini, Livio^5,6 (AUTHOR), Ronsisvalle, Simone⁷ (AUTHOR), Zanocco-Marani, Tommaso¹ (AUTHOR), Brasili, Livio¹ (AUTHOR), Lanfrancone, Luisa³ (AUTHOR), Imbriano, Carol¹ (AUTHOR), Di Rocco, Giulia¹ (AUTHOR) giulia.dirocco@unimore.it, Franchini, Silvia¹ (AUTHOR) giulia.dirocco@unimore.it

Publikováno v: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9684. 20p.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity

Autor: Franchini, Silvia, Sorbi, Claudia, Linciano, Pasquale, Carnevale, Gianluca, Tait, Annalisa, Ronsisvalle, Simone, Buccioni, Michela, Del Bello, Fabio, Cilia, Antonio, Pirona, Lorenza, Denora, Nunzio, Iacobazzi, Rosa Maria, Brasili, Livio

Publikováno v: In European Journal of Medicinal Chemistry 15 August 2019 176:310-325

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists

Autor: Franchini, Silvia, Manasieva, Leda Ivanova, Sorbi, Claudia, Battisti, Umberto M., Fossa, Paola, Cichero, Elena, Denora, Nunzio, Iacobazzi, Rosa Maria, Cilia, Antonio, Pirona, Lorenza, Ronsisvalle, Simone, Aricò, Giuseppina, Brasili, Livio

Publikováno v: In European Journal of Medicinal Chemistry 5 January 2017 125:435-452

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Autor: Linciano, Pasquale, Pinzi, Luca, Belluti, Silvia, Chianese, Ugo, Benedetti, Rosaria, Moi, Davide, Altucci, Lucia, Franchini, Silvia, Imbriano, Carol, Sorbi, Claudia, Rastelli, Giulio

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2080-2086 (2021)

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HD

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