Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Soraya Scuderi"'
Autor:
Hanna E. Stevens, Soraya Scuderi, Sarah C. Collica, Simone Tomasi, Tamas L. Horvath, Flora M. Vaccarino
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fibroblast growth factor receptor 2 (FGFR2) is almost exclusively expressed in glial cells in postnatal mouse brain, but its impact in glia for brain behavioral functioning is poorly understood. We compared behavioral effects from FGFR2 loss
Externí odkaz:
https://doaj.org/article/24fca8045f194d03bdf9c4af93006b7f
Publikováno v:
International Journal of Endocrinology, Vol 2015 (2015)
Enduring diabetes increases the probability of developing secondary damage to numerous systems, and these complications represent a cause of morbidity and mortality. Establishing the causes of diabetes remains the key step to eradicate the disease, b
Externí odkaz:
https://doaj.org/article/5ce6f3ebd1e64d70a02d552759016b68
Autor:
Soraya Scuderi, Flora M. Vaccarino, Vincenzo Cimini, Gianfilippo Coppola, Giovanna Giuseppina Altobelli
Publikováno v:
Stem Cell Reports
Summary Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distinct
Autor:
L. Manlove, Fritz J. Sedlazeck, Maria Kalyva, Taejeong Bae, Shobana Sekar, Yeongjun Jang, Flora M. Vaccarino, Jessica Mariani, Bo Zhou, Soraya Scuderi, Anahita Amiri, Alexej Abyzov, Livia Tomasini, Christos Proukakis, Alexander E. Urban
Publikováno v:
Genome Res
Somatic mosaicism, manifesting as single nucleotide variants (SNVs), mobile element insertions, and structural changes in the DNA, is a common phenomenon in human brain cells, with potential functional consequences. Using a clonal approach, we previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517591e8a41c2e249ae61b7f27abbbbc
https://europepmc.org/articles/PMC7706730/
https://europepmc.org/articles/PMC7706730/
Autor:
Xiaoxu, Yang, Xin, Xu, Martin W, Breuss, Danny, Antaki, Laurel L, Ball, Changuk, Chung, Jiawei, Shen, Chen, Li, Renee D, George, Yifan, Wang, Taejeong, Bae, Yuhe, Cheng, Alexej, Abyzov, Liping, Wei, Ludmil B, Alexandrov, Jonathan L, Sebat, Soraya, Scuderi
Publikováno v:
Nature biotechnology.
Mosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs has been computationally challenging due
Publikováno v:
Curr Opin Genet Dev
In this review we discuss the importance of genetic somatic mosaicism and its impact on brain diseases. We start from introducing the different types of somatic mutations, their frequencies and abundances across development and lifespan. We then desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43324a0ce5c8a94905e37f4ff21b41c
https://europepmc.org/articles/PMC7749073/
https://europepmc.org/articles/PMC7749073/
Publikováno v:
Neuropsychopharmacology
Crucial decisions involving cell fate and connectivity that shape the distinctive development of the human brain occur in the embryonic and fetal stages-stages that are difficult to access and investigate in humans. The last decade has seen an impres
Autor:
Alexej Abyzov, Kevin Cameron Allan, Anahita Amiri, Heather M. Brown, Anne L. Calof, Qiang Chang, Kimberly M. Christian, Benjamin L.L. Clayton, Francesca Cucinotta, Alissa M. D'Gama, Mathew Sean Elitt, L. Fernandez, R. Holly Fitch, Jeffrey A. Golden, Laura Groves, R.J. Hagerman, Eric Jaffe, B.L. Johnson-Kerner, Alexandre Jourdon, Arthur D. Lander, M.J. Leigh, Youngshin Lim, A.H. Mahnke, Jessica Mariani, Guo-li Ming, R.C. Miranda, S.M. Mooney, Jeffrey L. Neul, Zachary Scott Nevin, Lee Niswander, Christopher Oliver, Antonio M. Persico, Sofia A. Pezoa, Christina Pyrgaki, Lawrence T. Reiter, Arianna Ricciardello, Edward Rubenstein, Mustafa Sahin, Rosaysela Santos, Soraya Scuderi, E.H. Sherr, Hongjun Song, Siddharth Srivastava, Paul J. Tesar, Laura Turriziani, Flora M. Vaccarino, Christopher A. Walsh, Feinan Wu, Eunice Y. Yuen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647b4f4ae80f0afd2ea6367a538313df
https://doi.org/10.1016/b978-0-12-814409-1.01002-8
https://doi.org/10.1016/b978-0-12-814409-1.01002-8
Autor:
Alexandre Jourdon, Flora M. Vaccarino, Eunice Y. Yuen, Anahita Amiri, Soraya Scuderi, Alexej Abyzov, Feinan Wu, Jessica Mariani
Induced pluripotent stem cells (iPSCs) have opened an important chapter in the study of neurodevelopment. They allow the study of species, such as humans and primates, whose accessibility to experimentation was previously limited or impossible. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8f863d08f571aa92d026c8cefcaf03
https://doi.org/10.1016/b978-0-12-814409-1.00005-7
https://doi.org/10.1016/b978-0-12-814409-1.00005-7
Publikováno v:
Journal of the American Academy of Child & Adolescent Psychiatry. 60:S201