Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Soraya Manaviazar"'
1
Osteopontin (OPN) Downregulatory Alkaloid (-)-Agelastatin A Prevents Muscle Damage in a Mouse Model of Duchenne Muscular Dystrophy
Autor: Soraya Manaviazar, Sara Mata López, Karl J. Hale, Peter P. Nghiem, Hamish A. Watson, Madison Feng
(-)-Agelastatin A (AA) in 1,2-propanediol (3-deoxy-DL-glycerol) elicits a dose-dependent decrease in OPN mRNA expression in canine Duchenne Muscular Dystrophy (DMD) myoblasts at doses ranging from 0.01 nM-30 nM. When intraperitoneally administered in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0bcb5c3ce310153cce833886577f64
https://doi.org/10.26434/chemrxiv.14210882
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2
Fast Ring-Opening of an Intermediary α-Stannyl-β-Cyclopropylvinyl Radical Does Not Support Formation of an α-Stannylvinyl Cation in the O-Directed Free Radical Hydrostannation of Dialkyl Acetylenes
Autor: Hannah G. Steeds, Karl J. Hale, Hamish A. Watson, Soraya Manaviazar
Publikováno v: Watson, H A, Manaviazar, S, Steeds, H G & Hale, K J 2019, ' Fast ring-opening of an intermediary α-stannyl-β-cyclopropylvinyl radical does not support formation of an α-stannylvinyl cation in the O-directed free radical hydrostannation of dialkyl acetylenes ', Chemical Communications . https://doi.org/10.1039/c9cc05492h
O-Directed free radical hydrostannation of a β-cyclopropyl propargylic alcohol probe with stannanes and cat. Et3B in THF/H2O, or PhMe/MeOH, failed to deliver any detectable products of α-stannylvinyl cation capture. Instead only α-stannyl-β-cyclo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e31b7cc9a3eab1a67e9da76479947
https://doi.org/10.26434/chemrxiv.8867651
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3
The stannylvinyl cation that never was! New concentration- and temperature-dependent probe studies confirm an entirely free radical mechanism and O–Sn coordinative control of the hydrostannation of propargylically-oxygenated dialkyl acetylenes with stannanes and cat. Et3B
Autor: Soraya Manaviazar, Hannah G. Steeds, Karl J. Hale, Hamish A. Watson
Publikováno v: Watson, H A, Manaviazar, S, Steeds, H G & Hale, K 2020, ' The stannylvinyl cation that never was! New concentration-and temperature-dependent probe studies confirm an entirely free radical mechanism and O–Sn coordinative control of the hydrostannation of propargylically-oxygenated dialkyl acetylenes with stannanes and cat. Et3B ', Tetrahedron . https://doi.org/10.1016/j.tet.2020.131061
O-Directed free radical hydrostannation of the β-cyclopropyl propargyl alcohol 57 with stannanes and cat. Et3B in THF/H2O or PhMe/MeOH failed to deliver any of the expected products of α-stannylvinyl cation capture. Instead only α-stannyl-β-cyclo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef30a3f41c7744210fa6defbad0828c
https://doi.org/10.1016/j.tet.2020.131061
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4
On the halogenation of N (1), N (2)-di- t -Boc-5-hydroxy-piperazic acid esters and the conformational preferences of their 5-halo-piperazic acid products. The importance of A 1,3 rotameric-strain in determining N (2)-acyl piperazic acid ring conformation
Autor: Karl J. Hale, Soraya Manaviazar, Paul J. Stevenson
Publikováno v: Tetrahedron Letters. 56:3662-3666
In this Letter, an unambiguous synthetic strategy is reported for the preparation of enantiomerically pure cis -5-halo-piperazic acid derivatives in single diastereoisomer form. Contrary to the recent report by Shin and co-workers ( Chem. Lett . 2001
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9639150a914e6db20bd0c56106450ee
https://doi.org/10.1016/j.tetlet.2015.04.062
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5
Rules and Stereoelectronic Guidelines for the Anionic Nucleophilic Displacement of Furanoside and Furanose O-Sulfonates
Autor: Karl J. Hale, Leslie Hough, Soraya Manaviazar, Andrew Calabrese
Publikováno v: Hale, K J, Hough, L, Manaviazar, S & Calabrese, A 2015, ' Rules and Stereoelectronic Guidelines for the Anionic Nucleophilic Displacement of Furanoside and Furanose O-sulfonates ', Organic Letters, vol. 17, no. 7, pp. 1738-1741 . https://doi.org/10.1021/acs.orglett.5b00511
Rules for predicting anionic SN2 displacement viability in furanose and furanoside sulfonates are presented
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bd127602509c675af71b5343e674f3
https://doi.org/10.1021/acs.orglett.5b00511
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6
The O-Directed Free Radical Hydrostannation of Propargyloxy Dialkyl Acetylenes with Ph
Autor: Karl J, Hale, Soraya, Manaviazar, Hamish A, Watson
Publikováno v: Chemical record (New York, N.Y.). 19(2-3)
In this Personal Account, we will give an overview of the room temperature O-directed free radical hydrostannation reaction of propargylically-oxygenated dialkyl acetylenes with Ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99b92dec2215f87286030fcc8bf420fa
https://pubmed.ncbi.nlm.nih.gov/30411498
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7
An Update of the Rules for Pyranoside Sulfonate Displacement
Autor: Karl J. Hale, Andrew Calabrese, Leslie Hough, Soraya Manaviazar
Publikováno v: Organic Letters. 16:4838-4841
The original 1967 Richardson-Hough rules for predicting SN2 displacement viability in carbohydrate sulfonate derivatives with external nucleophiles have now been updated. Not only do the original rules still hold, but the newly updated rules rational
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15868e02dc4dcc660578bc27d545e584
https://doi.org/10.1021/ol502193j
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8
Total Synthesis of the GRP78-Downregulatory Macrolide (+)-Prunustatin A, the Immunosuppressant (+)-SW-163A, and a JBIR-04 Diastereoisomer That Confirms JBIR-04 Has Nonidentical Stereochemistry to (+)-Prunustatin A
Autor: Soraya Manaviazar, Peter Nockemann, Karl J. Hale
Publikováno v: Manaviazar, S, Nockemann, P & Hale, K J 2016, ' Total Synthesis of the GRP78-Downregulatory Macrolide (+)-Prunustatin A, the Immunosuppressant (+)-SW-163A, and a JBIR-04 Diastereoisomer That Confirms JBIR-04 Has Nonidentical Stereochemistry to (+)-Prunustatin A ', Organic Letters, vol. 18, pp. 2902-2905 . https://doi.org/10.1021/acs.orglett.6b01235
A unified total synthesis of the GRP78-downregulator (+)-prunustatin A and the immunosuppressant (+)-SW-163A based upon [1 + 1 + 1 + 1]-fragment condensation and macrolactonization between O(4) and C(5) is herein described. Sharpless asymmetric dihyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511e11ea12e22c1fb7aa38f9c77a6d35
https://pubmed.ncbi.nlm.nih.gov/27232270
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10
Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP
Autor: John R. Heemstra, Wei Jiang, Frank C. Schroeder, Ry R. Forseth, Karl J. Hale, Soraya Manaviazar, Christopher S. Neumann, Christopher T. Walsh
Publikováno v: Biochemistry
Kutznerides 2 and 8 of the cyclic hexadepsipeptide family of antifungal natural products from the soil actinomycete Kutzneria sp. 744 contain two sets of chlorinated residues, a 6,7-dichlorohexahydropyrroloindole moiety derived from dichlorotryptopha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bb5323d4809606a7dbaa27c75c51a0
https://doi.org/10.1021/bi200656k
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