Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Soraia Melo"'
Autor:
Joana Pereira, Soraia Melo, Rui M. Ferreira, Patrícia Carneiro, Vítor Yang, André F. Maia, João Carvalho, Ceu Figueiredo, José Carlos Machado, Eurico Morais-de-Sá, Raquel Seruca, Joana Figueiredo
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such as oral facial clefts (OFC). However, the molecular mechanisms through which E-cadherin loss-of-function tr
Externí odkaz:
https://doaj.org/article/96a6f8b1d7c04624a648032db1a5a0ef
Autor:
Soraia Melo, Pilar Guerrero, Maurício Moreira Soares, José Rafael Bordin, Fátima Carneiro, Patrícia Carneiro, Maria Beatriz Dias, João Carvalho, Joana Figueiredo, Raquel Seruca, Rui D. M. Travasso
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly invasive cancer syndrome characterised by the occurrence of diffuse-type gastric carcinoma and lobular breast cancer. In this disease, E-cadherin-defec
Externí odkaz:
https://doaj.org/article/cf546053fed94afea7fc40377b3b573e
Autor:
Hemaxi Narotamo, Maria Sofia Fernandes, Ana Margarida Moreira, Soraia Melo, Raquel Seruca, Margarida Silveira, João Miguel Sanches
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The cell nucleus is a tightly regulated organelle and its architectural structure is dynamically orchestrated to maintain normal cell function. Indeed, fluctuations in nuclear size and shape are known to occur during the cell cycle and alter
Externí odkaz:
https://doaj.org/article/ad30e0a2942d469a9a290f003248ca72
Autor:
Joana Figueiredo, Soraia Melo, Kimberley Gamet, Tanis Godwin, Susana Seixas, João M. Sanches, Parry Guilford, Raquel Seruca
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-7 (2018)
Abstract The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the signal peptide of E-cadherin w
Externí odkaz:
https://doaj.org/article/7ff09f3f7a124c11ba668e246b5162a2
Autor:
Ana Margarida Moreira, Joana Pereira, Soraia Melo, Maria Sofia Fernandes, Patrícia Carneiro, Raquel Seruca, Joana Figueiredo
Publikováno v:
Cells, Vol 9, Iss 2, p 394 (2020)
The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition
Externí odkaz:
https://doaj.org/article/2164fa638ad2493d935dbe6d0c5214a0
Autor:
Soraia Melo, Joana Figueiredo, Maria Sofia Fernandes, Margarida Gonçalves, Eurico Morais-de-Sá, João Miguel Sanches, Raquel Seruca
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2687 (2017)
The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in
Externí odkaz:
https://doaj.org/article/fc66c9a4209b4e8f9f4ad2e94ce1df0e
Autor:
Cristina Amaral, Margarida Borges, Soraia Melo, Elisiário Tavares da Silva, Georgina Correia-da-Silva, Natércia Teixeira
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42398 (2012)
Aromatase inhibitors (AIs), which block the conversion of androgens to estrogens, are used for hormone-dependent breast cancer treatment. Exemestane, a steroidal that belongs to the third-generation of AIs, is a mechanism-based inhibitor that binds c
Externí odkaz:
https://doaj.org/article/4d3bbfecb5714b93a74de20f12261c29
Autor:
Joana Pereira, Soraia Melo, Patrícia Carneiro, Maria Sofia Fernandes, Joana Figueiredo, Raquel Seruca
Publikováno v:
Hereditary Gastric and Breast Cancer Syndrome ISBN: 9783031213168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce2761cdb20459c6986ea101b1db855
https://doi.org/10.1007/978-3-031-21317-5_6
https://doi.org/10.1007/978-3-031-21317-5_6
Autor:
Ana Margarida Moreira, Margarida Silveira, Maria Sofia Fernandes, Joao Sanches, Hemaxi Narotamo, Soraia Melo, Raquel Seruca
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The cell nucleus is a tightly regulated organelle and its architectural structure is dynamically orchestrated to maintain normal cell function. Indeed, fluctuations in nuclear size and shape are known to occur during the cell cycle and alterations in
Autor:
Joana Figueiredo, Joana Pereira, Rui M. Ferreira, Luísa Carvalho, Margarida Gonçalves, Soraia Melo, Patrícia Carneiro, Parry Guilford, Eurico Morais-de-Sá, Raquel Seruca
Publikováno v:
Cancer Research. 83:5815-5815
Introduction: Cell invasion is a critical step for tumor progression and dissemination into neighboring and distant tissues, which constitute the foremost cause of cancer mortality. Loss of the cell-cell adhesion molecule E-cadherin occurs in 70% of