Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sorabh Agarwal"'
Autor:
Kunhua Li, Olena S. Tokareva, Ty M. Thomson, Sebastian C. T. Wahl, Tara L. Travaline, Jessica D. Ramirez, Santosh K. Choudary, Sorabh Agarwal, Ward G. Walkup, Tivoli J. Olsen, Matthew J. Brennan, Gregory L. Verdine, John H. McGee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(52)
The α-helix is one of the most common protein surface recognition motifs found in nature, and its unique amide-cloaking properties also enable α-helical polypeptide motifs to exist in membranes. Together, these properties have inspired the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd6b9d4ca8e5ed4e4242f16217e6ee7
https://pubmed.ncbi.nlm.nih.gov/36534810
https://pubmed.ncbi.nlm.nih.gov/36534810
Autor:
Brian H. White, Yaguang Si, Sarah Cappucci, Zhi Li, Jessica D. Ramirez, Charles M. Ponthier, Erica Visness, Peicheng Du, Minjung Choi, Pieter C. Beerepoot, Paula C. Ortet, Ivan T. Jewett, Josue Alfaro-Lopez, Sorabh Agarwal, Daniel La, Aaron Fulgham, John H. McGee, Keith Orford, Jonathan B. Hurov, Martin R. Tremblay, Gregory L. Verdine
Publikováno v:
Cancer Research. 83:3094-3094
Wnt signaling pathway mutations leading to constitutive activation of the driver oncogene β-catenin occur in at least 20% of all human cancers, but β-catenin itself has remained undruggable by traditional modalities. In order to inhibit the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c51d264aae8f3a219530f16aa966065
https://doi.org/10.1158/1538-7445.am2023-3094
https://doi.org/10.1158/1538-7445.am2023-3094
Autor:
YaGuang Si, Minjung Choi, Xinwei Han, Brian White, Ziyang Wu, Erica Visness, Pieter Beerepoot, Elizabeth Jaensch, Jessica Ramirez, Charles Ponthier, Xiaogang Han, Paula Ortet, Peicheng Du, Sorabh Agarwal, Mirek Lech, Aaron Fulgham, Sarah Cappucci, Zhi Li, John McGee, Lihua Yu, Martin Tremblay, Keith Orford, Gregory Verdine, Jonathan Hurov
Publikováno v:
Cancer Research. 83:4972-4972
Genetic and epigenetic alterations in the Wnt signaling pathway leading to constitutive activation of the driver oncogene Β-catenin occur in at least 20% of all human cancers. We have developed conformationally hyperstabilized α-helical peptides (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22644786ea70a7faf3e1da4e9ed1da32
https://doi.org/10.1158/1538-7445.am2023-4972
https://doi.org/10.1158/1538-7445.am2023-4972
Autor:
Yaguang Si, Brian White, Sarah Cappucci, Jessica Ramirez, Charles Ponthier, Erica Visness, Kevin Ling, Peicheng Du, Minjung Choi, Ty Thomson, Josue Alfaro-Lopez, Pieter Beerepoot, Sorabh Agarwal, Paula Ortet, Miroslaw Lech, Zhi Li, Voké Olokpa, Ivan Jewett, Daniel La, Lihua Yu, John McGee, Martin Tremblay, Jonathan Hurov, Greg Verdine
Publikováno v:
Cancer Research. 82:345-345
Wnt pathway mutations can be found in nearly all colorectal cancers and a significant number of cancers of the liver, breast, prostate, endometrium and lung, among others. β-catenin is a key signaling hub in the Wnt pathway. Activated nuclear β-cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d8db76a6cc2f26f0c55baee31ade013
https://doi.org/10.1158/1538-7445.am2022-345
https://doi.org/10.1158/1538-7445.am2022-345