Supplementary Figure S3 from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

Supplementary Figure S3: OC ascites fluid activates the classical and alternative pathways.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e9d0756f962f510cedda4ba0a9a0f6
https://doi.org/10.1158/2326-6066.22543210.v1

Supplementary Figure S1 from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

Supplementary Figure S1: Gating strategies for flow cytometry and Image-stream.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115a03c9dc90a336c90a575f2b469874
https://doi.org/10.1158/2326-6066.22543216

Supplementary Figure S6 from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

Supplementary Figure S6: Evaluation of NFAT and NF-kB translocation, glucose uptake and phosphorylation of p70S6 kinase in CD4+ T cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e87c1f371f9c9d9d6e243809308bc1
https://doi.org/10.1158/2326-6066.22543198

Data from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

T-cell activation and expansion in the tumor microenvironment (TME) are critical for antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell suppressor phenotype that is characterized by inhibition of T-cell proliferation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d4f40cc451070fd401b4b199f38dd0
https://doi.org/10.1158/2326-6066.c.6550174

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells

Autor: Brahm H. Segal, Thejaswini Giridharan, Sora Suzuki, ANM Nazmul H. Khan, Emese Zsiros, Tiffany R. Emmons, Michael B. Yaffe, Angela A. F. Gankema, Mark Hoogeboom, Ines Goetschalckx, Hanke L. Matlung, Taco W. Kuijpers

Publikováno v: Segal, B H, Giridharan, T, Suzuki, S, Khan, A NM N H, Zsiros, E, Emmons, T R, Yaffe, M B, Gankema, A A F, Hoogeboom, M, Goetschalckx, I, Matlung, H L & Kuijpers, T W 2022, ' Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells ', Immunological Reviews . https://doi.org/10.1111/imr.13178

Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial products against pathogens. Neutrophils are also activated by damage-associated molecular patterns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9149e610fe37ff4c684d46012fa3ed
https://research.vumc.nl/en/publications/d719a9bf-5d75-497d-9dac-c77c7457343a