Supplementary Tables from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

Supplementary Tables 1-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a13f6bea6ac0d91539043db8f72237
https://doi.org/10.1158/2326-6066.22543195

Data from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

T-cell activation and expansion in the tumor microenvironment (TME) are critical for antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell suppressor phenotype that is characterized by inhibition of T-cell proliferation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d4f40cc451070fd401b4b199f38dd0
https://doi.org/10.1158/2326-6066.c.6550174

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells

Autor: Brahm H. Segal, Thejaswini Giridharan, Sora Suzuki, ANM Nazmul H. Khan, Emese Zsiros, Tiffany R. Emmons, Michael B. Yaffe, Angela A. F. Gankema, Mark Hoogeboom, Ines Goetschalckx, Hanke L. Matlung, Taco W. Kuijpers

Publikováno v: Segal, B H, Giridharan, T, Suzuki, S, Khan, A NM N H, Zsiros, E, Emmons, T R, Yaffe, M B, Gankema, A A F, Hoogeboom, M, Goetschalckx, I, Matlung, H L & Kuijpers, T W 2022, ' Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells ', Immunological Reviews . https://doi.org/10.1111/imr.13178

Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial products against pathogens. Neutrophils are also activated by damage-associated molecular patterns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9149e610fe37ff4c684d46012fa3ed
https://research.vumc.nl/en/publications/d719a9bf-5d75-497d-9dac-c77c7457343a

Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model

Autor: Sora Suzuki, Thejaswini Giridharan, ANM Nazmul Khan, Tiffany R Emmons, Michael B. Yaffe, Kipp Weiskopf, Madhumita Das, Kevin H. Eng, Emese Zsiros, Brahm H. Segal

Publikováno v: The Journal of Immunology. 208:176.14-176.14

Epithelial ovarian cancer (OC) is the most lethal gynecological malignancy. While OC is an immunogenic tumor, single-agent anti-PD-1 have limited efficacy in recurrent OC. Blockade of the CD47/SIRPα pathway, a phagocytosis checkpoint in macrophages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64c9255e2697e2654994679f7a3bc589
https://doi.org/10.4049/jimmunol.208.supp.176.14

Mature neutrophils acquire a T cell suppressor phenotype in the ovarian cancer microenvironment characterized by disruption of key T cell signaling and metabolic responses

Autor: Thejaswini Giridharan, Tiffany R Emmons, ANM Nazmul Khan, Sora Suzuki, Aaron Varghese, Meagan Sullivan, Kunle Odunsi, Emese Zsiros, Michael B Yaffe, Brahm H Segal

Publikováno v: The Journal of Immunology. 206:101.05-101.05

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Despite being an immunogenic tumor, single-agent checkpoint inhibitor therapy in the recurrent setting has been disappointing, raising the notion of suppressive factors in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07a72b4d7b12f20bd2f242f177451a5d
https://doi.org/10.4049/jimmunol.206.supp.101.05