Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sophronia A. Lewis"'
Autor:
Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
AMPK modulates idiopathic and hypoxic pulmonary hypertension in adults, largely via unknown mechanisms. Here, the authors show that AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new born and premature death in mice
Externí odkaz:
https://doaj.org/article/3376d21907c9443c9accb7061aa04379
Autor:
Marc Foretz, Sandy MacMillan, Benoit Viollet, Javier Moral-Sanz, D. Grahame Hardie, Carmel M. Moran, Sophronia A. Lewis, A. Mark Evans, Fiona A. Ross, Adrian Thomson
Publikováno v:
Science Signaling
Science Signaling, American Association for the Advancement of Science, 2018, 11 (550), pp.eaau0296. ⟨10.1126/scisignal.aau0296⟩
Moral-Sanz, J, Lewis, S A, MacMillan, S, Ross, F A, Thomson, A, Viollet, B, Foretz, M, Moran, C, Hardie, D G & Evans, A M 2018, ' The LKB1-AMPK-α1 signalling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria ', Science Signaling, vol. 11, no. 550 . https://doi.org/10.1126/scisignal.aau0296
Science Signaling, American Association for the Advancement of Science, 2018, 11 (550), pp.eaau0296. ⟨10.1126/scisignal.aau0296⟩
Moral-Sanz, J, Lewis, S A, MacMillan, S, Ross, F A, Thomson, A, Viollet, B, Foretz, M, Moran, C, Hardie, D G & Evans, A M 2018, ' The LKB1-AMPK-α1 signalling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria ', Science Signaling, vol. 11, no. 550 . https://doi.org/10.1126/scisignal.aau0296
International audience; Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The unique sensitivity of these muscles to hypoxia is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c754dea92d6a8f84a902dff8e5998ade
https://hal.archives-ouvertes.fr/hal-02348836
https://hal.archives-ouvertes.fr/hal-02348836
Publikováno v:
Advances in experimental medicine and biology. 860
Perhaps the defining characteristic of pulmonary arteries is the process of hypoxic pulmonary vasoconstriction (HPV) which, under physiological conditions, supports ventilation-perfusion matching in the lung by diverting blood flow away from oxygen d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8fd456fdbc662b0f033279b389dc1b4
https://pubmed.ncbi.nlm.nih.gov/26303471
https://pubmed.ncbi.nlm.nih.gov/26303471
Publikováno v:
The FASEB Journal. 29
The AMP-activated protein kinase (AMPK) has been proposed to underpin appropriate cardiorespiratory adjustments during hypoxia (Evans et al., 2006), and has been identified as a mediator of hypoxic...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::992e6927e7e3f6f7b9d4226186349ba6
https://doi.org/10.1096/fasebj.29.1_supplement.682.1
https://doi.org/10.1096/fasebj.29.1_supplement.682.1
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319184395
Perhaps the defining characteristic of pulmonary arteries is the process of hypoxic pulmonary vasoconstriction (HPV) which, under physiological conditions, supports ventilation-perfusion matching in the lung by diverting blood flow away from oxygen d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0899af22e786d9acd769b6dc72370782
https://doi.org/10.1007/978-3-319-18440-1_11
https://doi.org/10.1007/978-3-319-18440-1_11