Výsledky vyhledávání - "Sophronia A. Lewis"

Akademický článek

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Autor: Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

AMPK modulates idiopathic and hypoxic pulmonary hypertension in adults, largely via unknown mechanisms. Here, the authors show that AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new born and premature death in mice

Externí odkaz: https://doaj.org/article/3376d21907c9443c9accb7061aa04379

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The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Autor: Marc Foretz, Sandy MacMillan, Benoit Viollet, Javier Moral-Sanz, D. Grahame Hardie, Carmel M. Moran, Sophronia A. Lewis, A. Mark Evans, Fiona A. Ross, Adrian Thomson

Publikováno v: Science Signaling
Science Signaling, American Association for the Advancement of Science, 2018, 11 (550), pp.eaau0296. ⟨10.1126/scisignal.aau0296⟩
Moral-Sanz, J, Lewis, S A, MacMillan, S, Ross, F A, Thomson, A, Viollet, B, Foretz, M, Moran, C, Hardie, D G & Evans, A M 2018, ' The LKB1-AMPK-α1 signalling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria ', Science Signaling, vol. 11, no. 550 . https://doi.org/10.1126/scisignal.aau0296

International audience; Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The unique sensitivity of these muscles to hypoxia is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c754dea92d6a8f84a902dff8e5998ade
https://hal.archives-ouvertes.fr/hal-02348836

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Modulation of the LKB1-AMPK Signalling Pathway Underpins Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

Autor: A Mark, Evans, Sophronia A, Lewis, Oluseye A, Ogunbayo, Javier, Moral-Sanz

Publikováno v: Advances in experimental medicine and biology. 860

Perhaps the defining characteristic of pulmonary arteries is the process of hypoxic pulmonary vasoconstriction (HPV) which, under physiological conditions, supports ventilation-perfusion matching in the lung by diverting blood flow away from oxygen d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8fd456fdbc662b0f033279b389dc1b4
https://pubmed.ncbi.nlm.nih.gov/26303471

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AMP‐activated Protein Kinase is Necessary for Cardiorespiratory Adjustments during Hypoxia

Autor: A Evans, Javier Moral-Sanz, Sophronia A. Lewis

Publikováno v: The FASEB Journal. 29

The AMP-activated protein kinase (AMPK) has been proposed to underpin appropriate cardiorespiratory adjustments during hypoxia (Evans et al., 2006), and has been identified as a mediator of hypoxic...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::992e6927e7e3f6f7b9d4226186349ba6
https://doi.org/10.1096/fasebj.29.1_supplement.682.1

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