Výsledky vyhledávání - "Sophie Zahalka"

Akademický článek

Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner.

Autor: Martin L Watzenboeck, Barbara Drobits, Sophie Zahalka, Anna-Dorothea Gorki, Asma Farhat, Federica Quattrone, Anastasiya Hladik, Karin Lakovits, Gabriel M Richard, Therese Lederer, Birgit Strobl, Gijs A Versteeg, Louis Boon, Philipp Starkl, Sylvia Knapp

Publikováno v: PLoS Pathogens, Vol 17, Iss 4, p e1009487 (2021)

Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron uptake and exerts immunomodulatory functions in various diseases. Here, we aimed to characte

Externí odkaz: https://doaj.org/article/350841de659e460bb7aad2175ab5017b

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Murine Ex Vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function

Autor: Brigitte Langer, Renate Kain, Karin Lakovits, Veronika Sexl, Anastasiya Hladik, Barbara Maurer, Anna-Dorothea Gorki, Sophie Zahalka, Sylvia Knapp, Dörte Symmank

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 66:64-75

Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44dcf0e39c8527a37507845113a06454
https://doi.org/10.1165/rcmb.2021-0190oc

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Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling

Autor: Sophie Zahalka, Philipp Starkl, Martin L. Watzenboeck, Asma Farhat, Mariem Radhouani, Florian Deckert, Anastasiya Hladik, Karin Lakovits, Felicitas Oberndorfer, Caroline Lassnig, Birgit Strobl, Kristaps Klavins, Mai Matsushita, David E. Sanin, Katarzyna M. Grzes, Edward J. Pearce, Anna-Dorothea Gorki, Sylvia Knapp

Publikováno v: Mucosal immunology : official journal of the Society for Mucosal Immunology

Environmental microbial triggers shape the development and functionality of the immune system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in constant and direct contact with inhaled particles and microbes. Such exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e948b4d94254705339eee42ebf2d2c1
https://hdl.handle.net/21.11116/0000-000D-147C-221.11116/0000-000D-147E-0

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Murine

Autor: Anna-Dorothea, Gorki, Dörte, Symmank, Sophie, Zahalka, Karin, Lakovits, Anastasiya, Hladik, Brigitte, Langer, Barbara, Maurer, Veronika, Sexl, Renate, Kain, Sylvia, Knapp

Publikováno v: American journal of respiratory cell and molecular biology. 66(1)

Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a novel culture model to study and expand murine primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db709055326ff23e46af2388c0666b44
https://pubmed.ncbi.nlm.nih.gov/34735777

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Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

Autor: Renate Kain, Anastasiya Hladik, Sophie Zahalka, Karin Lakovits, Sylvia Knapp, Barbara Maurer, Brigitte Langer, Dörte Symmank, Veronika Sexl, Anna-Dorothea Gorki

SUMMARYTissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a novel culture model to study and expand murine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ee5e8805e2871010f58c2f446a1b96f
https://doi.org/10.1101/2021.02.11.430791

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IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus

Autor: Frédéric Fontaine, Lukas Stulik, Stephen J. Galli, Nicolas Gaudenzio, Karin Lakovits, Thomas Marichal, Riccardo Sibilano, Arvand Haschemi, Manuel R. Amieva, Martin L. Watzenboeck, Sylvia Knapp, Philipp Starkl, Lauren M. Popov, Laurent L. Reber, Anastasiya Hladik, André C. Mueller, Sophie Zahalka, Mariem Radhouani

Publikováno v: Immunity
Immunity, Elsevier, 2020, 53 (6), pp.1333. ⟨10.1016/j.immuni.2020.11.012⟩
Immunity, Elsevier, 2020, 53 (4), pp.793-804. ⟨10.1016/j.immuni.2020.08.002⟩

International audience; Allergies are considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous compounds. Immunoglobulin E (IgE) antibodies are a characteristic feature of allergies and mediate hypersensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748d3ddf8210d76bab7a2dbd21c1e6e4
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03149668

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Multi-Omics Correlations Reveal Lipid Species Involved in Lung Allograft Adaptation

Autor: Sophie Zahalka, Stefanie Widder, Christopher Lambers, Federica Quattrone, Stefan Schwarz, Konrad Hoetzenecker, Philipp Starkl, Peter Jaksch, Nina Rahimi, Tyler Artner, Riem Gawish, Karin Lakovits, Martin L. Watzenboeck, Anna-Dorothea Gorki, Sylvia Knapp, Dörte Symmank

Publikováno v: The Journal of Heart and Lung Transplantation. 40:S333-S334

Purpose Allograft adaptation after lung transplantation is a multi-factor process. We hypothesized that early adaptation can influence the risk of matrix remodeling and CLAD development by shaping the inflammatory state of the lung environment. In a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91e3bdba350ce6fb7ef7894a8bbdecc8
https://doi.org/10.1016/j.healun.2021.01.939

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Multi-omics profiling predicts allograft function after lung transplantation

Publikováno v: European Respiratory Journal. 59:2003292

RationaleLung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears the highest mortality rate among all solid organ transplantations due to chronic lung allograft dysfunction (CLAD). The mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed84150c608441b3b17ccbff7c5bea7f
https://doi.org/10.1183/13993003.03292-2020

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Bronchoalveolar Lavage Lipidomic Profiles Can Predict Short-Term Changes in Lung Function in Lung Transplant Recipients

Autor: Walter Klepetko, Stefanie Widder, Peter Jaksch, Sylvia Knapp, Stefan Schwarz, Karin Lakovits, Federica Quattrone, Riem Gawish, Sophie Zahalka, N. Fortelny, Tyler Artner, Philipp Starkl, Dörte Symmank, Christopher Lambers, Anna-Dorothea Gorki, Martin L. Watzenboeck, Konrad Hoetzenecker

Publikováno v: The Journal of Heart and Lung Transplantation. 39:S114

Purpose Spirometric lung function is one of the central clinical parameters to assess allograft function after lung transplantation (LTX). Reduction in FEV1 can be the result of infections, rejections episodes and most importantly development of CLAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c7017350ed4481c66651805a656f4a
https://doi.org/10.1016/j.healun.2020.01.987

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Temporal Dynamics of the Pulmonary Microbiome after Lung Transplantation

Autor: Sophie Zahalka, Stefan Schwarz, Stefanie Widder, N. Fortelny, Tyler Artner, Federica Quattrone, Philipp Starkl, Sylvia Knapp, Karin Lakovits, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker, Dörte Symmank, Anna-Dorothea Gorki, Riem Gawish, Martin L. Watzenboeck, Christopher Lambers

Publikováno v: The Journal of Heart and Lung Transplantation. 39:S115

Purpose The pulmonary microbiome after lung transplantation has recently come into the focus of research. Especially, host-microbiome interactions are thought to be an important factor in graft-related immunological processes. In lung transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57c00dc3b93d450dc6df704ae12d3107
https://doi.org/10.1016/j.healun.2020.01.989

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