Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sophie X, Peng"'
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
Supplementary Figures S1-S3, Tables S1-S7. Suppl. Figure S1: Prolif. Curves, PC3 Cell Cycle & solid tumor apoptosis Suppl. Figure S2: PK/PD Model Performance and eIF4E In Vivo Biomarker Suppl. Figure S3: HCT-116, MBA MD231 & A549 Efficacy Studies Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1
https://doi.org/10.1158/1535-7163.22500843.v1
Autor:
John F. Boylan, Jennifer R. Riggs, Heather K. Raymon, Ning Jiang, Tao Shi, Yuhong Ning, David Mikolon, Tam Tran, Rama Krishna Narla, Leo A. Barnes, Sophie X. Peng, Gordafaried Deyanat-Yazdi, Shuichan Xu, Dan Zhu
Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a phenotypic screen for compounds that preferentially induced apoptosis in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc39d765a5b86cd0bea57f9dd0bcd25
https://doi.org/10.1158/1535-7163.c.6537733
https://doi.org/10.1158/1535-7163.c.6537733
Autor:
John F. Boylan, Jennifer R. Riggs, Heather K. Raymon, Ning Jiang, Tao Shi, Yuhong Ning, David Mikolon, Tam Tran, Rama Krishna Narla, Leo A. Barnes, Sophie X. Peng, Gordafaried Deyanat-Yazdi, Shuichan Xu, Dan Zhu
SUPPLEMENTAL METHODS • Correlative analysis of CC-671 sensitivity data with genomic features in the 240 Oncopanel • Correlative analysis of CC-671 sensitivity data with genomic features or tumor subtypes in 49 breast cancer cell lines â
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345d2d16f0cdc9dbe61ef20d892594b3
https://doi.org/10.1158/1535-7163.22504438.v1
https://doi.org/10.1158/1535-7163.22504438.v1
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1
https://doi.org/10.1158/1535-7163.c.6536589.v1
Autor:
Shuichan Xu, Ning Jiang, Rama K. Narla, Jennifer Riggs, Tao Shi, Sophie X. Peng, Yuhong Ning, Heather Raymon, Dan Zhu, Gordafaried Deyanat-Yazdi, David Mikolon, John F. Boylan, Leo Barnes, Tam Tran
Publikováno v:
Molecular Cancer Therapeutics. 17:1727-1738
Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a phenotypic screen for compounds that preferentially induced apoptosis in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273b7f2034f8d7318e39b7bd2a91e6af
https://doi.org/10.1158/1535-7163.mct-17-1084
https://doi.org/10.1158/1535-7163.mct-17-1084
Autor:
Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
Publikováno v:
Journal of Medicinal Chemistry. 58:5599-5608
We report here the synthesis and structure-activity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors. SAR studies examining the potency, selectivity, and PK parameters for a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4246303bd0bfbb72482c44adc512f
https://doi.org/10.1021/acs.jmedchem.5b00627
https://doi.org/10.1021/acs.jmedchem.5b00627
Autor:
Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
Publikováno v:
Journal of Medicinal Chemistry. 58:5323-5333
We report here the synthesis and structure-activity relationship (SAR) of a novel series of mammalian target of rapamycin (mTOR) kinase inhibitors. A series of 4,6- or 1,7-disubstituted-3,4-dihydropyrazino[2,3-b]pyrazine-2(1H)-ones were optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45fdcea6d9d36fd9f5e210e377f686
https://doi.org/10.1021/acs.jmedchem.5b00626
https://doi.org/10.1021/acs.jmedchem.5b00626
Autor:
Jingjing Zhao, Sophie X. Peng, Brian E. Cathers, Sabita Sankar, Garrick Packard, Stacie S. Canan, Shuichan Xu, Heather Raymon, Godrej Khambatta, Rama K. Narla, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Matt Hickman, Tam Tran, Samantha J. Richardson, Jim Leisten, Kamran Ghoreishi, Rene Bissonette, Mehran F. Moghaddam, Julius Apuy, Tao Shi, Deborah Mortensen, Wen Qing Yang, Weiming Xu, James C. Gamez, Peter Worland, Zeen Tong
Publikováno v:
Molecular Cancer Therapeutics. 14:1295-1305
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50876b20cd6236c0e871976f53e0b444
https://doi.org/10.1158/1535-7163.mct-14-1052
https://doi.org/10.1158/1535-7163.mct-14-1052
Autor:
Dan, Zhu, Shuichan, Xu, Gordafaried, Deyanat-Yazdi, Sophie X, Peng, Leo A, Barnes, Rama Krishna, Narla, Tam, Tran, David, Mikolon, Yuhong, Ning, Tao, Shi, Ning, Jiang, Heather K, Raymon, Jennifer R, Riggs, John F, Boylan
Publikováno v:
Molecular cancer therapeutics. 17(8)
Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a phenotypic screen for compounds that preferentially induced apoptosis in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::417f65d7df09ef47540d0fb0902ded11
https://pubmed.ncbi.nlm.nih.gov/29866747
https://pubmed.ncbi.nlm.nih.gov/29866747
Autor:
David Mikolon, Sophie X. Peng, Dan Zhu, Rama K. Narla, Jennifer Riggs, John F. Boylan, Yuhong Ning, Gordafaried Deyanat-Yazdi
Publikováno v:
Molecular Cancer Therapeutics. 17:B177-B177
Historically, synthetic lethal-based drug discovery has yielded a high percentage of novel, first-in-class drugs while uncovering new tumor biology. Using a synthetic lethal approach, we identified one compound that preferentially induced apoptosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17875bde9bd0a22c9ba976030b579427
https://doi.org/10.1158/1535-7163.targ-17-b177
https://doi.org/10.1158/1535-7163.targ-17-b177