Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Sophie Vieweg"'
1
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72
Autor: Katie Mulholland, Rachel Toth, Miratul M. K. Muqit, Ilaria Volpi, Bastian Bräuning, Sophie Vieweg, Aymelt Itzen, Yu-Chiang Lai, Nitin Kachariya, Michael Groll, Michael Sattler, Pawan Singh
Publikováno v: Biochemical Journal
Loss of function mutations in the PTEN-induced kinase 1 (PINK1) kinase are causal for autosomal recessive Parkinson's disease (PD) whilst gain of function mutations in the LRRK2 kinase cause autosomal dominant PD. PINK1 indirectly regulates the phosp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d40eba02b94bccd950e541beb96c89b
http://europepmc.org/articles/PMC7219890
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2
Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks
Autor: Aymelt Itzen, Danial Pourjafar-Dehkordi, Martin Zacharias, Sophie Vieweg
Publikováno v: Biochemistry. 58:3546-3554
GTPases are key-players in cellular signaling processes. Phosphorylation of Rab proteins, which belong to the Ras superfamily of small GTPases regulating intracellular transport, has recently been implicated in the pathogenesis of Parkinson Disease (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3cc22e08dcda669afdfb1c579bf21c
https://doi.org/10.1021/acs.biochem.9b00516
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4
Unraveling the Complexity of Amyloid Polymorphism Using Gold Nanoparticles and Cryo-EM
Autor: Marie Müller, Francesco Tavanti, Nadine Ait-Bouziad, Paulo Jacob Silva, Sophie Vieweg, Francesco Stellacci, Maria Cristina Menziani, Zekiye Pelin Guven, Urszula Cendrowska, Marcus Fändrich, Senthil Kumar, Hilal A. Lashuel, Alfredo Alexander-Katz, Anass Chiki, Lynn Radamaker
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance The ability of proteins to self-assemble into different types of fibrils with distinct morphologies has been linked to the pathological and clinical heterogeneity of amyloid diseases such as Alzheimer’s disease and Parkinson’s diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ad4ae917aa1d2654c89bafd9fea266
https://doi.org/10.1101/754846
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5
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72
Autor: Michael Sattler, Yu-Chiang Lai, Bastian Bräuning, Aymelt Itzen, Katie Mulholland, Rachel Toth, Michael Groll, Sophie Vieweg, Miratul M. K. Muqit, Nitin Kachariya
Loss of function mutations in the PINK1 kinase are causal for autosomal recessive Parkinson disease (PD) whilst gain of function mutations in the LRRK2 kinase cause autosomal dominant PD. PINK1 indirectly regulates the phosphorylation of a subset of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd789168fe3da57e4884554995c8d8b
https://doi.org/10.1101/764019
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6
An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
Autor: Sophie Vieweg, Annalisa Ansaloni, Hilal A. Lashuel, Zhe Ming Wang, John B. Warner
Publikováno v: Journal of Biological Chemistry. 291:12074-12086
The first exon of the Huntingtin protein (Httex1) is one of the most actively studied Htt fragments because its overexpression in R6/2 transgenic mice has been shown to recapitulate several key features of Huntington disease. However, the majority of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fd115ca2988f4efe0c492d35f315c1
https://doi.org/10.1074/jbc.m116.713982
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8
Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Autor: Urszula Cendrowska, Anass Chiki, Sophie Vieweg, Hilal A. Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Giovanni Dietler
Publikováno v: Scientific reports (Nature Publishing Group) 6 (2016). doi:10.1038/srep31155
info:cnr-pdr/source/autori:Ruggeri, F. S.; Vieweg, S.; Cendrowska, U.; Longo, G.; Chiki, A.; Lashuel, H. A.; Dietler, G./titolo:Nanoscale studies link amyloid maturity with polyglutamine diseases onset/doi:10.1038%2Fsrep31155/rivista:Scientific reports (Nature Publishing Group)/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Scientific Reports 6 (2016)
Scientific Reports, 6
Scientific Reports
Europe PubMed Central
The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington’s disease. However, the molecular and structural basis underlying the increased t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774b5f0e130679a005afa8ed2563744e
https://publications.cnr.it/doc/376985
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9
Locking GTPases covalently in their functional states
Autor: Fu Li, Frank Hofmann, Matthias P. Müller, Roger S. Goody, Aymelt Itzen, Daniel Koch, Sophie Vieweg, David Wiegandt, Yao-Wen Wu
Publikováno v: Nature Communications
GTPases act as key regulators of many cellular processes by switching between active (GTP-bound) and inactive (GDP-bound) states. In many cases, understanding their mode of action has been aided by artificially stabilizing one of these states either
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6184fe8341271836b4ce292da96875
https://pubmed.ncbi.nlm.nih.gov/26178622
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10
One-pot Semisynthesis Of Exon1 Of The Mutant Huntingtin Protein: An Important Advance Towards Elucidating The Molecular And Structural Determinants Of Huntingtin's Aggregation And Toxicity
Autor: Ritwik Burai, Sean M. DeGuire, Anass Chiki, Sophie Vieweg, Hilal A. Lashuel
Publikováno v: Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1.
Huntington's disease (HD) is a fatal genetic neurodegenerative disorder caused by a CAG expansion gene which is translated into a polyglutamine stretch within the first exon of the Huntingtin protein (Htt). HD patients suffer from motor impairments,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6545ecda81c49f3ba17a6d83a0bf0241
https://doi.org/10.5339/qfarc.2014.hbpp1047
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