Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sophie TURBAN"'
Autor:
Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J. Rosen, Vicky E. MacRae, Jose Luis Millán, Colin Farquharson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulat
Externí odkaz:
https://doaj.org/article/23dc81b350d5458086f9e23af1515cc1
Autor:
Clothilde Philouze, Sophie Turban, Beatrice Cremers, Audrey Caliez, Gwladys Lamarche, Catherine Bernard, Nicolas Provost, Philippe Delerive
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245179 (2021)
In type 2 diabetes (T2D), both muscle and liver are severely resistant to insulin action. Muscle insulin resistance accounts for more than 80% of the impairment in total body glucose disposal in T2D patients and is often characterized by an impaired
Externí odkaz:
https://doaj.org/article/2e41387e5ace419ba419dee08cdd1431
Autor:
Silvia M A Pedroni, Sophie Turban, Tiina Kipari, Donald R Dunbar, Kerry McInnes, Philippa T K Saunders, Nicholas M Morton, Jane E Norman
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94680 (2014)
Maternal obesity is linked with increased adverse pregnancy outcomes for both mother and child. The metabolic impact of excessive fat within the context of pregnancy is not fully understood. We used a mouse model of high fat (HF) feeding to induce ma
Externí odkaz:
https://doaj.org/article/6b662fd06b84406aad7689baadb0057f
Autor:
Rana Mahfouz, Rhéa Khoury, Agnieszka Blachnio-Zabielska, Sophie Turban, Nicolas Loiseau, Christopher Lipina, Clare Stretton, Olivier Bourron, Pascal Ferré, Fabienne Foufelle, Harinder S Hundal, Eric Hajduch
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101865 (2014)
Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of insulin-stimulated glucose disposal. Depending on cell type, these lipid intermediates have been shown
Externí odkaz:
https://doaj.org/article/def06baf965243abac56d022f12b7e5c
Autor:
Martin E. Barrios-Llerena, Derek Ball, Zohreh Khavandgar, Lutz Bünger, Anyonya R. Guntur, Colin Farquharson, Karla J. Suchacki, Clifford J. Rosen, Sophie Turban, Monzur Murshed, Mathieu Ferron, Carmen Huesa, Nicholas M. Morton, Benjamin J. Thomas, José Luis Millán, William P. Cawthorn, Manisha C. Yadav, Vicky E MacRae, Gerard Karsenty, Calvin P.H. Vary
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Suchacki, K, Morton, N M, Vary, C, Huesa, C, Yadav, M, Thomas, B, Turban, S, Bungar, L, Ball, D, Barrios-Llerena, M, Guntur, A, Khavandgar, Z, Cawthorn, W P, Ferron, M, Karsenty, G, Murshed, M, Rosen, C J, MacRae, V, Millan, J-L & Farquharson, C 2020, ' PHOSPHO1 is a skeletal regulator of insulin resistance and obesity ', BMC Biology, vol. 18, no. 149, 149 (2020) . https://doi.org/10.1186/s12915-020-00880-7
BMC Biology
Suchacki, K, Morton, N M, Vary, C, Huesa, C, Yadav, M, Thomas, B, Turban, S, Bungar, L, Ball, D, Barrios-Llerena, M, Guntur, A, Khavandgar, Z, Cawthorn, W P, Ferron, M, Karsenty, G, Murshed, M, Rosen, C J, MacRae, V, Millan, J-L & Farquharson, C 2020, ' PHOSPHO1 is a skeletal regulator of insulin resistance and obesity ', BMC Biology, vol. 18, no. 149, 149 (2020) . https://doi.org/10.1186/s12915-020-00880-7
BMC Biology
Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulator of met
Autor:
Audrey Caliez, Clothilde Philouze, Catherine Bernard, Philippe Delerive, Béatrice Cremers, Sophie Turban, Nicolas Provost, Gwladys Lamarche
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0245179 (2021)
PLoS ONE, Vol 16, Iss 2, p e0245179 (2021)
In type 2 diabetes (T2D), both muscle and liver are severely resistant to insulin action. Muscle insulin resistance accounts for more than 80% of the impairment in total body glucose disposal in T2D patients and is often characterized by an impaired
Autor:
Alexander Gray, Olivier Drouin, André Marette, Maria L. Watson, Louise Lantier, Harinder S. Hundal, Charlotte J. Green, Benoit Viollet, Sophie Turban, Fiona A. Ross, Clare Stretton, D. Grahame Hardie
Publikováno v:
The Journal of Biological Chemistry
Background: The role of AMPK and PKCs as effectors of metformin action on glucose uptake (GU) in skeletal muscle cells was investigated. Results: Genetic loss/silencing of AMPK led to only a small repression in metformin-stimulated GU. Novel/conventi
Autor:
Brian R. Walker, Scott P. Webster, Donald R. Dunbar, Nicholas M. Morton, X. Liu, Sophie Turban, Lynne Ramage, John J. Mullins, Jonathan R. Seckl
Publikováno v:
Diabetes
Turban, S, Liu, X, Ramage, L, Webster, S P, Walker, B R, Dunbar, D R, Mullins, J J, Seckl, J R & Morton, N M 2012, ' Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure ', Diabetes, vol. 61, no. 3, pp. 642-652 . https://doi.org/10.2337/db11-1054
Turban, S, Liu, X, Ramage, L, Webster, S P, Walker, B R, Dunbar, D R, Mullins, J J, Seckl, J R & Morton, N M 2012, ' Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure ', Diabetes, vol. 61, no. 3, pp. 642-652 . https://doi.org/10.2337/db11-1054
Type 2 diabetes ultimately results from pancreatic β-cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in fat or liver may underlie pathophysiological a
Autor:
Zoi Michailidou, Brian R. Walker, Nicholas M. Morton, John P. Iredale, Sophie Turban, Patrick W. F. Hadoke, Jonathan R. Seckl, Xiantong Zou, Peter J. Ratcliffe, Joerg Schrader, Eileen Miller
Publikováno v:
Journal of Biological Chemistry; Vol 287
The Journal of Biological Chemistry
Michailidou, Z, Turban, S, Miller, E, Zou, X, Schrader, J, Ratcliffe, P J, Hadoke, P W F, Walker, B R, Iredale, J P, Morton, N M & Seckl, J R 2012, ' Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice ', Journal of Biological Chemistry, vol. 287, no. 6, pp. 4188-4197 . https://doi.org/10.1074/jbc.M111.259325
The Journal of Biological Chemistry
Michailidou, Z, Turban, S, Miller, E, Zou, X, Schrader, J, Ratcliffe, P J, Hadoke, P W F, Walker, B R, Iredale, J P, Morton, N M & Seckl, J R 2012, ' Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice ', Journal of Biological Chemistry, vol. 287, no. 6, pp. 4188-4197 . https://doi.org/10.1074/jbc.M111.259325
Background: Adipose hypertrophy limits fat cell oxygenation, promotes scarring, and associates with increased local glucocorticoid regeneration (higher 11βHSD1 enzyme). Results: 11βHSD1 knock-out mice have reduced scarring and better vascularizatio
Autor:
Kei Sakamoto, J. Simon C. Arthur, Eric Hajduch, Victoria A. Beardmore, Julia M. Carr, Sophie Turban, Harinder S. Hundal
Publikováno v:
Diabetes. 54:3161-3168
It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the pl