Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sophie Sierro"'
Publikováno v:
Bio-Protocol, Vol 4, Iss 16 (2014)
Different vaccine and adjuvant combinations are known to rapidly induce antigen presenting cell (APC) maturation and pro-inflammatory cytokine and production, which in turn play an important role in the priming of antigen-specific T cells. Measuring
Externí odkaz:
https://doaj.org/article/4f6f1ac920114a738fafcb9d0e43a05c
Publikováno v:
Bio-Protocol, Vol 4, Iss 16 (2014)
Measuring antigen-specific T cell responses in the blood and lymphoid organs of vaccinated mice can give us a useful indication of the potency of a vaccine formulation. Unfortunately, systemic or even localized lymphoid T cell responses are not alway
Externí odkaz:
https://doaj.org/article/af9a09184bf74a3984631db22a8ca278
Autor:
Ulrike Träger, Sophie Sierro, Gordana Djordjevic, Basma Bouzo, Shivani Khandwala, Antonella Meloni, Monika Mortensen, Anna Katharina Simon
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35005 (2012)
The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic
Externí odkaz:
https://doaj.org/article/ed1a3d63284a4a8086304ef2c13716d8
Autor:
Luisa Cervantes-Barragan, Roland Züst, Reinhard Maier, Sophie Sierro, Jozef Janda, Frederic Levy, Daniel Speiser, Pedro Romero, Pierre-Simon Rohrlich, Burkhard Ludewig, Volker Thiel
Publikováno v:
mBio, Vol 1, Iss 4 (2010)
ABSTRACT Efficient vaccination against infectious agents and tumors depends on specific antigen targeting to dendritic cells (DCs). We report here that biosafe coronavirus-based vaccine vectors facilitate delivery of multiple antigens and immunostimu
Externí odkaz:
https://doaj.org/article/e25819499c9c49ca9527573fd48a887c
Autor:
Andrew K. Sewell, Thomas J. Scriba, Eric L. Brown, Sophie Sierro, Rodney E. Phillips, Ruth C. Massey
The extracellular adhesion protein (Eap) secreted by the major human pathogenStaphylococcus aureusis known to have several effects on human immunity. We have recently added to knowledge of these roles by demonstrating that Eap enhances interactions b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4966b53019ba7a986001299315bd246a
https://doi.org/10.1128/iai.01699-07
https://doi.org/10.1128/iai.01699-07
Autor:
Annette Oxenius, Urs Karrer, Paul Klenerman, Ulrich H. Koszinowski, Markus Wagner, Hartmut Hengel, Tilman Dumrese, Stefan Freigang, Sophie Sierro, Rodney E. Phillips
CD8+T cells are critical for the control of many persistent viral infections, such as human immunodeficiency virus, hepatitis C virus, Epstein-Barr virus, and cytomegalovirus (CMV). In most infections, large CD8+-T-cell populations are induced early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b35a48c13e8104d5fa232f63b5ea06
https://doi.org/10.1128/jvi.78.5.2255-2264.2004
https://doi.org/10.1128/jvi.78.5.2255-2264.2004
Publikováno v:
Journal of The Royal Society Interface. 4:533-543
Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f752b24f9d9627e8dfda93287134333
https://doi.org/10.1098/rsif.2006.0195
https://doi.org/10.1098/rsif.2006.0195
Publikováno v:
The Journal of Immunology. 177:450-458
CMVs are β herpesviruses that establish lifelong latent infection of their hosts. Acute infection of C57BL/6 mice with murine CMV elicits a very broad CD8 T cell response, comprising at least 24 epitopes from 18 viral proteins. In contrast, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ac8aa32b09f6aa33c277864513fe83
https://doi.org/10.4049/jimmunol.177.1.450
https://doi.org/10.4049/jimmunol.177.1.450
Publikováno v:
European Journal of Immunology. 35:1113-1123
Cytomegalovirus (CMV) is a major human pathogen normally controlled by cellular immune responses. The infection can be modeled in the mouse using murine CMV (MCMV). During the latent phase of infection, two different patterns of CD8(+) T cell respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edcac68e2f7b2a45e3ebc35920776ae
https://doi.org/10.1002/eji.200425534
https://doi.org/10.1002/eji.200425534
Publikováno v:
Clinical and Experimental Immunology. 134:9-12
SUMMARY MHC class I-peptide tetrameric complexes (‘tetramers’) have revolutionized the study of antiviral CD8+ T cell responses. They allow accurate quantification of immune responses ex vivo independent of function, with high levels of sensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8111058bfa6b1ccbea008ab1eab276e
https://doi.org/10.1046/j.1365-2249.2003.02266.x
https://doi.org/10.1046/j.1365-2249.2003.02266.x