Výsledky vyhledávání - "Sophie Peigné"

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

Autor: Marylore Chenel, Emmanuelle Comets, Marc Cerou, Sophie Peigné

Publikováno v: AAPS Journal
AAPS Journal, 2020, 22 (1), pp.4. ⟨10.1208/s12248-019-0379-x⟩
AAPS Journal, American Association of Pharmaceutical Scientists, 2020, 22 (1), pp.4. ⟨10.1208/s12248-019-0379-x⟩

International audience; INTRODUCTION:In this paper, we studied the effect over time of agomelatine, an antidepressant drug administered in patient with major depressive disorder, through item response theory (IRT), taking into account a strong placeb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0662b51a194aff2865d1694b2080f0
https://doi.org/10.1208/s12248-019-0379-x

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Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment

Autor: Marylore Chenel, Sophie Decourcelle, Sylvain Fouliard, Sophie Peigné

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 43:29-43

The objectives of this work were first to describe the pharmacokinetic (PK) of ivabradine and its active metabolite in a paediatric patient population after repeated oral administration of ivabradine using a population PK approach, and secondly to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae6fa628bb57ecb44dcfdcd69586705
https://doi.org/10.1007/s10928-015-9452-y

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Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment

Autor: Charlotte Gesson, Sylvain Fouliard, Marylore Chenel, François Bouzom, Sophie Peigné, Karl Brendel

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 43:13-27

The main objective was to help design a paediatric study for ivabradine, a compound already marketed in adults, focusing on: the paediatric formulation evaluation, the doses to be administered, the sampling design and the sampling technique. A second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0158a8c04081a40b334ea5549bbfdc2
https://doi.org/10.1007/s10928-015-9451-z

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Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

Autor: Stéphanie Chhun, Elisabeth Rey, Sophie Peigné, Christelle Rodrigues, Vincent Jullien, Gérard Pons, Michel Tod, Catherine Chiron

Publikováno v: Clinical pharmacokinetics. 57(6)

The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg twice-daily dose. Thirty-five children wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730276ce5a4aa813510cb31996fe2eaf
https://pubmed.ncbi.nlm.nih.gov/28819726

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