Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sophie P. Syddall"'
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Supplementary Data from Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1a13337fc2c96e19e47692ba0a48b4
https://doi.org/10.1158/1535-7163.22482483.v1
https://doi.org/10.1158/1535-7163.22482483.v1
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Hypoxia represents an important therapeutic target in tumors because of the resistance of hypoxic cells to radiotherapy and chemotherapy and because it is more severe in many tumors than in normal tissues. Here, we describe a class of prodrugs, nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714841c611cd9afe078394aa781cbc2d
https://doi.org/10.1158/1535-7163.c.6530940.v1
https://doi.org/10.1158/1535-7163.c.6530940.v1
Autor:
Dean C. Singleton, Sophie P. Syddall, Amir Ashoorzadeh, Alexandra M. Mowday, Dan Li, Jeff B. Smaill, Christopher P. Guise, Sally Y. Bai, William R. Wilson, Adam V. Patterson
Publikováno v:
Cancer Gene Therapy. 29:1021-1032
Advances in the field of cancer immunotherapy have stimulated renewed interest in adenoviruses as oncolytic agents. Clinical experience has shown that oncolytic adenoviruses are safe and well tolerated but possess modest single-agent activity. One ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27638279eb5fc7da46196d6b720e6e2
https://doi.org/10.1038/s41417-021-00409-2
https://doi.org/10.1038/s41417-021-00409-2
Autor:
R. Biemans, Maria R. Abbattista, Philippe Lambin, Ludwig Dubois, Sophie P. Syddall, Jan Theys, Alexandra M. Mowday, N. Lieuwes, Christopher P. Guise, Janine N. Copp, Amir Ashoorzadeh, Elsie M. Williams, David F. Ackerley, Jingli Wang, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Theranostics
Theranostics, 10(23), 10548-10562. Ivyspring International Publisher
Theranostics, 10(23), 10548-10562. Ivyspring International Publisher
The use of reporter genes to non-invasively image molecular processes inside cells has significant translational potential, particularly in the context of systemically administered gene therapy vectors and adoptively administered cells such as immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b726db7d1f04c1e9ab609dd8f61d1
http://europepmc.org/articles/PMC7482819
http://europepmc.org/articles/PMC7482819
Autor:
Dean C, Singleton, Alexandra M, Mowday, Chris P, Guise, Sophie P, Syddall, Sally Y, Bai, Dan, Li, Amir, Ashoorzadeh, Jeff B, Smaill, William R, Wilson, Adam V, Patterson
Publikováno v:
Cancer gene therapy. 29(7)
Advances in the field of cancer immunotherapy have stimulated renewed interest in adenoviruses as oncolytic agents. Clinical experience has shown that oncolytic adenoviruses are safe and well tolerated but possess modest single-agent activity. One ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa59f458eb6c41ecf84cdd8f6a865e94
https://pubmed.ncbi.nlm.nih.gov/34837065
https://pubmed.ncbi.nlm.nih.gov/34837065
Autor:
Jeffrey Bruce Smaill, Adam V. Patterson, William R. Wilson, Gareth A. Prosser, Emrys Williams, David F. Ackerley, Sophie P. Syddall, Janine N. Copp
Publikováno v:
Biochemical Pharmacology. 79:678-687
Gene-directed enzyme prodrug therapy (GDEPT) aims to achieve highly selective tumor-cell killing through the use of tumor-tropic gene delivery vectors coupled with systemic administration of otherwise inert prodrugs. Nitroaromatic prodrugs such as CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c066fbbf0e4630504e520224926b90
https://doi.org/10.1016/j.bcp.2009.10.008
https://doi.org/10.1016/j.bcp.2009.10.008
Publikováno v:
Molecules
Molecules, Vol 14, Iss 11, Pp 4517-4545 (2009)
Molecules, Vol 14, Iss 11, Pp 4517-4545 (2009)
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert non-toxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9feaa9c0986f7485408b76924d2ce9
http://europepmc.org/articles/PMC6255103
http://europepmc.org/articles/PMC6255103
Autor:
Adam V. Patterson, Sally Y. Bai, William R. Wilson, Dan Li, William A. Denny, Dean C. Singleton, Yuqiao Shen, Sophie P. Syddall, Jeffrey Bruce Smaill
Publikováno v:
Cancer Gene Therapy. 14:953-967
Conditionally replicating adenoviruses (CRAd) 'armed' with prodrug-activating genes have the potential to augment the efficacy of virotherapy. An Escherichia coli nitroreductase (NTR) gene (nfsB) was introduced into the E3B region of the systemically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10244ced2b7b8abbca5018d706fe1f6
https://doi.org/10.1038/sj.cgt.7701088
https://doi.org/10.1038/sj.cgt.7701088
Autor:
Christopher P. Guise, Adam V. Patterson, Janine N. Copp, Elsie M. Williams, Gareth A. Prosser, Jeff B. Smaill, Claire N. Horvat, William A. Denny, David F. Ackerley, Alexandra M. Mowday, Amir Ashoorzadeh, Sophie P. Syddall, Pearl M. Swe
Publikováno v:
Biochemical pharmacology. 85(8)
Two potentially complementary approaches to improve the anti-cancer strategy gene-directed enzyme prodrug therapy (GDEPT) are discovery of more efficient prodrug-activating enzymes, and development of more effective prodrugs. Here we demonstrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583047f6ddb5cdebeeb4fd6117a2dd98
https://pubmed.ncbi.nlm.nih.gov/23399641
https://pubmed.ncbi.nlm.nih.gov/23399641
Autor:
Frederik B. Pruijn, H. D. Sarath Liyanage, Stephen M. Stribbling, Eileen Smith, Moana Tercel, William R. Wilson, Sophie P. Syddall, Adam V. Patterson, K. Jane Botting
Publikováno v:
Molecular cancer therapeutics. 8(10)
Hypoxia represents an important therapeutic target in tumors because of the resistance of hypoxic cells to radiotherapy and chemotherapy and because it is more severe in many tumors than in normal tissues. Here, we describe a class of prodrugs, nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aac189ea906732976047a08a4f0474
https://pubmed.ncbi.nlm.nih.gov/19808982
https://pubmed.ncbi.nlm.nih.gov/19808982