Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sophie Ottema"'
Autor:
Sophie Ottema, Roger Mulet-Lazaro, Claudia Erpelinck-Verschueren, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H. Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J. Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line an
Externí odkaz:
https://doaj.org/article/7df6196de175464e8b50bb614eba9c97
Autor:
Jagoda Mika, Sophie Ottema, Sandra Kiehlmeier, Sabrina Kruse, Leonie Smeenk, Judith Müller, Sabrina Schweiggert, Carl Herrmann, Mathijs Sanders, Ruud Delwel, Stefan Gröschel
Publikováno v:
Haematologica, Vol 106, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/8960bf988b65429c8688d75ea7829095
Autor:
Marije Havermans, Eric M.J. Bindels, Leonie Smeenk, Peter J. M. Valk, Stanley van Herk, Claudia Erpelinck, Roger Mulet-Lazaro, H. Berna Beverloo, Ruud Delwel, Robert van der Helm, Sophie Ottema, Torsten Haferlach, Claudia Haferlach, Tim Grob
Publikováno v:
Blood, 136(2), 224-234. American Society of Hematology
Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct World Health Organization recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39746508b6b6cca70aa9cad92ddee879
https://pure.eur.nl/en/publications/acc03a4d-3b41-4de1-bdde-b1ef97734c2f
https://pure.eur.nl/en/publications/acc03a4d-3b41-4de1-bdde-b1ef97734c2f
Autor:
H. Berna Beverloo, Ruud Delwel, Eric Bindels, Marije Havermans, Sophie Ottema, Stefan Gröschel, Michael Vermeulen, Bas J. Wouters, Torsten Haferlach, Leonie Smeenk, Claudia A.J. Erpelinck-Verschueren, Claudia Haferlach, Roger Mulet-Lazaro, Andrea Arricibita Varea, Stanley van Herk
Publikováno v:
Nature Communications, 12(1):5679. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39af26ea606ee42cf0d14c739198eca
https://pure.eur.nl/en/publications/04f21b77-cbaa-43f7-a02e-7d978a9554bd
https://pure.eur.nl/en/publications/04f21b77-cbaa-43f7-a02e-7d978a9554bd
Autor:
Ruud Delwel, Eric M.J. Bindels, Sophie Ottema, Marije Havermans, Emery H. Bresnick, François G. Kavelaars, Andrea Arricibita Varea, Johannes Zuber, Alex Kentsis, Remco Hoogenboezem, Anja Ebert, Roger Mulet-Lazaro, Tim Grob, Daniel R. Matson, Dorien Pastoors, Michaela Fellner, Stanley van Herk, Claudia A.J. Erpelinck-Verschueren, Leonie Smeenk
Publikováno v:
Cancer Discov
Cancer Discovery, 11(11), 2868-2883. American Association for Cancer Research Inc.
Cancer Discovery, 11(11), 2868-2883. American Association for Cancer Research Inc.
In acute myeloid leukemia (AML) with inv(3)(q21;q26) or t(3;3)(q21;q26), a translocated GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML model and applied an unbiased CRISPR/Cas9 enhancer scan to uncover sequence motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb3dbdca13f4f0ef37917d89572b412
https://pubmed.ncbi.nlm.nih.gov/33980539
https://pubmed.ncbi.nlm.nih.gov/33980539
Autor:
Kris Leslie, Dick H. W. Dekkers, Luca Signorile, Niels Galjart, Joyce H.G. Lebbink, Nuo Yu, Sophie Ottema, Sreya Basu, Jeroen Demmers, Ihor Smal
Publikováno v:
Current Biology, 26(13), 1728-1736. Cell Press
The microtubule (MT) cytoskeleton forms a dynamic filamentous network that is essential for many processes, including mitosis, cell polarity and shape, neurite outgrowth and migration, and ciliogenesis [1, 2]. MTs are built up of a/beta-tubulin heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cde25087524035161a05f750786ee3
https://pure.eur.nl/en/publications/ec7cca30-df85-4cef-9475-58796dd9b740
https://pure.eur.nl/en/publications/ec7cca30-df85-4cef-9475-58796dd9b740
Autor:
Peter J. M. Valk, Berna Beverloo, Marije Havermans, Claudia A.J. Erpelinck-Verschueren, Roger Mulet-Lazaro, Ruud Delwel, Leonie Smeenk, Eric M.J. Bindels, Claudia Haferlach, Tim Grob, Torsten Haferlach, Sophie Ottema
Publikováno v:
Blood. 132:2766-2766
Introduction Acute myeloid leukemia (AML) with inv(3)(q21q26) or t(3;3)(q21;q26) overexpress EVI1 and have a very poor prognosis. EVI1 is part of the MECOM (MDS1-EVI1-Combination) locus from which MDS1-EVI1 and EVI1 can be transcribed from two differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81ce607ab0b25a0e0dfad5eb7479e91
https://doi.org/10.1182/blood-2018-99-113339
https://doi.org/10.1182/blood-2018-99-113339
Autor:
Ottema, Sophie, Mulet-Lazaro, Roger, Erpelinck-Verschueren, Claudia, van Herk, Stanley, Havermans, Marije, Arricibita Varea, Andrea, Vermeulen, Michael, Beverloo, H. Berna, Gröschel, Stefan, Haferlach, Torsten, Haferlach, Claudia, J. Wouters, Bas, Bindels, Eric, Smeenk, Leonie, Delwel, Ruud
Publikováno v:
Nature Communications; 9/28/2021, Vol. 12 Issue 1, p1-13, 13p