Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sophie Mukadam"'
Autor:
Vanessa Strings-Ufombah, Alberto Malerba, Shih-Chu Kao, Sonal Harbaran, Fanny Roth, Ornella Cappellari, Ngoc Lu-Nguyen, Keiko Takahashi, Sophie Mukadam, Georgina Kilfoil, Claudia Kloth, Petrus Roelvink, George Dickson, Capucine Trollet, David Suhy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 67-78 (2021)
Oculopharyngeal muscular dystrophy (OPMD) is a rare autosomal dominant disease that results from an alanine expansion in the N-terminal domain of Poly-A Binding Protein Nuclear-1 (PABPN1). We have recently demonstrated that a two-vector gene therapy
Externí odkaz:
https://doaj.org/article/a38e66f16de34830a7d74e6ea8d9e973
Autor:
Sophie Mukadam, Jonathan Cheong, Leslie Wang, Hoa Le, Kang-Jye Chou, Xiaorong Liang, Deepak Sampath, Bianca M. Liederer, Jason Oeh, Peter S. Dragovich, Susan Wong, Justin Ly
Publikováno v:
Xenobiotica. 49:1063-1077
GNE-617 (N-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide) is a potent, selective nicotinamide phosphoribosyltransferase (NAMPT) inhibitor being explored as a potential treatment for human cancers.Plasma clearance was lo
Autor:
Justin Ly, Quynh Ho, Jialin Mao, Matthew Wright, Karen E. Parrish, Jacob Z. Chen, Sophie Mukadam, Allan Jaochico
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:200-211
1-Aminobenzotriazole (ABT) is a non-isoform specific, time-dependent inhibitor of cytochrome P450 (CYP) enzymes used extensively in preclinical studies to determine the relative contribution of oxidative metabolism. Although ABT has been widely used,
Autor:
Lisa Almond, M Jamei, K Rowland-Yeo, Suzanne Tay, Oliver Hatley, Sophie Mukadam, Krystle Okialda, Jane R. Kenny, Susan Wong, Iain Gardner, Amin Rostami-Hodjegan
Publikováno v:
Drug Metabolism and Disposition. 44:821-832
Using physiologically based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with rifampicin and seven CYP3A4 probe substrates administered i.v. (10 studies) or orally (19 studies). The results showed
Autor:
Divya Samineni, Sophie Mukadam, Cornelis E. C. A. Hop, Chunze Li, Harvey Wong, Jin Yan Jin, Sandhya Girish, Yuan Chen, Dan Lu, Ben-Quan Shen
Publikováno v:
Clinical Pharmacokinetics. 54:81-93
Monomethyl auristatin E (MMAE, a cytotoxic agent), upon releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is expected to behave like small molecules. Therefore, evaluating the drug–drug interaction (DDI) potential ass
Autor:
Janet Gunzner-Toste, Maureen Caligiuri, Nicholas J. Skelton, Jian Lin, Sophie Mukadam, Weiru Wang, Paul Bauer, Kenneth W. Bair, Xiaozhang Zheng, Karl H. Clodfelter, Bianca M. Liederer, Bang Fu, Thomas O'Brien, Zhongguo Wang, Peter S. Dragovich, Jasleen K. Sodhi, Lei Zhang, Geeta Sharma, Yen-Ching Ho, Chase C. Smith, Dominic J. Reynolds, Bingsong Han, Alexandre J. Buckmelter, Timm Baumeister, Angela Oh, Guiling Zhao, Nikolai Kley, Xiaorong Liang, Yang Xiao, Yuen Po-Wai, Mark Zak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3531-3538
Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This unwanted property was successfully removed from the described inhibitors t
Autor:
Erlie Marie Delarosa, Suzanne Tay, Leslie Wang, S. Cyrus Khojasteh, Jane R. Kenny, Sophie Mukadam, Jason Halladay, Daniel Tran
Publikováno v:
Drug Metabolism Letters. 6:43-53
Early in the drug discovery process, the identification of cytochrome P450 (CYP) time-dependent inhibition (TDI) is an important step for compound optimization. Here we describe a high-throughput, automated method for the evaluation of TDI utilizing
Autor:
Suzanne Tay, S. Cyrus Khojasteh, Jane R. Kenny, Aleksandra Galetin, Sophie Mukadam, Carol Collins, Chenghong Zhang
Publikováno v:
Pharmaceutical Research. 29:1960-1976
To evaluate 26 marketed oncology drugs for time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes. Evaluate TDI-positive drugs for potential to generate reactive intermediates. Assess clinical drug-drug interaction (DDI) risk using static m
Publikováno v:
Biopharmaceutics & Drug Disposition. 33:85-98
Prospective simulations of human pharmacokinetic (PK) parameters and plasma concentration-time curves using in vitro in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) models are becoming a vital part of the drug discovery
Autor:
Karen E, Parrish, Jialin, Mao, Jacob, Chen, Allan, Jaochico, Justin, Ly, Quynh, Ho, Sophie, Mukadam, Matthew, Wright
Publikováno v:
Biopharmaceuticsdrug disposition. 37(4)
1-Aminobenzotriazole (ABT) is a non-isoform specific, time-dependent inhibitor of cytochrome P450 (CYP) enzymes used extensively in preclinical studies to determine the relative contribution of oxidative metabolism. Although ABT has been widely used,