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Akademický článek
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Autor: Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, Robert J Ferrante, Wange Lu, Christian Neri
Publikováno v: PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway
Externí odkaz: https://doaj.org/article/30fe5f15c42b4abcbb453493275b5e19
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2
The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Autor: Olivia L. Bordiuk, Nicolas Offner, Anne-Marie Orfila, Robert J. Ferrante, Rafael P. Vázquez-Manrique, Michael M. Halford, Jinho Kim, Christina K. Edgerly, Wange Lu, Cendrine Tourette, Karen M. Smith, Anne Louise, Sonia Hernandez, Kerry Cormier, Jean-Philippe Vert, Si Ho Choi, Jungmok Lyu, J. Alex Parker, Francesca Farina, Steven A. Stacker, Christian Neri, Sophie Menet, Jessica Voisin
Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. 〈10.1371/journal.pbio.1001895〉
PLOS BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427bed9b6b241ccd95a774a759d7f997
https://hal.archives-ouvertes.fr/hal-01076146/file/journal.pbio.1001895-1.pdf
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