Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Autor: Edward A. Hayter, Sophie M. T. Wehrens, Hans P. A. Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J. Barron, Luigi A. Venetucci, John S. O’ Neill, Timothy M. Brown, Debra J. Skene, Andrew W. Trafford, David A. Bechtold

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time

Externí odkaz: https://doaj.org/article/530c60e952014c1cb2858a92a8c76775

Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Autor: Elena Crooks, Sophie M T Wehrens, Hans P. A. Van Dongen, Luigi Venetucci, Shobhan Gaddameedhi, Timothy M. Brown, John S. O’ Neill, Debra J. Skene, Andrew W. Trafford, Edward A. Hayter, Nichola J Barron, David A. Bechtold, Alessandra Stangherlin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Hayter, E A, Wehrens, S M T, Van Dongen, H P A, Stangherlin, A, Gaddameedhi, S, Crooks, E, Barron, N J, Venetucci, L A, Neill, J S O, Brown, T M, Skene, D J, Trafford, A W & Bechtold, D A 2021, ' Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia ', Nature Communications, vol. 12, no. 1, 2472 . https://doi.org/10.1038/s41467-021-22788-8

Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9799ab86b9df430aa2acc3f981e5e2a
https://doaj.org/article/530c60e952014c1cb2858a92a8c76775

Meal Timing Regulates the Human Circadian System

Autor: Sophie M T, Wehrens, Skevoulla, Christou, Cheryl, Isherwood, Benita, Middleton, Michelle A, Gibbs, Simon N, Archer, Debra J, Skene, Jonathan D, Johnston

Publikováno v: Current biology : CB. 27(12)

Circadian rhythms, metabolism, and nutrition are intimately linked [1, 2], although effects of meal timing on the human circadian system are poorly understood. We investigated the effect of a 5-hr delay in meals on markers of the human master clock a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdd73707cd49358d57ef1d5e55f6aa14
https://pubmed.ncbi.nlm.nih.gov/28697366

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers

Autor: Debra J. Skene, Shelagh M. Hampton, Sophie M T Wehrens

Publikováno v: Scandinavian Journal of Work, Environment & Health, Vol 38, Iss 2, Pp 171-181 (2012)

OBJECTIVES: Endothelial dysfunction and alterations in heart rate variability (HRV) as well as sleep deprivation and shift work have been associated with cardiovascular disease. The aim of this study was to compare HRV and endothelial function among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ce299e82bdde2ac2b8a62f3f338e5e
https://doi.org/10.5271/sjweh.3197

Noisy and individual, but doable: shift-work research in humans

Autor: Thomas, Kantermann, Sophie M T, Wehrens, Melissa A, Ulhôa, Claudia, Moreno, Debra J, Skene

Publikováno v: Progress in brain research. 199

Working around the clock is common for many occupations, as diverse as nurses, truck drivers, physicians, steel workers, and pilots. Each shift-work profession is individual in more aspects than just work hours and individual work scenarios, each pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::830ef1605c4a84d5d0601700f6f624f8
https://pubmed.ncbi.nlm.nih.gov/22877677