Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sophie M. Morgani"'
Autor:
Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental tra
Externí odkaz:
https://doaj.org/article/0d64cab140164afb8b8aaf26ab3db645
Publikováno v:
Biology Open, Vol 10, Iss 5 (2021)
During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation. At the same time, a small population of pluripotent cells give rise to t
Externí odkaz:
https://doaj.org/article/3a14b8d6b18f4711a71be5eb9505e413
Autor:
Javier Martin Gonzalez, Sophie M. Morgani, Robert A. Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch, Joshua M. Brickman
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 177-191 (2016)
Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in eit
Externí odkaz:
https://doaj.org/article/ebe5d83f8ce1449da14f67cbdc1edb8f
Autor:
Sophie M. Morgani, Maurice A. Canham, Jennifer Nichols, Alexei A. Sharov, Rosa Portero Migueles, Minoru S.H. Ko, Joshua M. Brickman
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1945-1957 (2013)
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with i
Externí odkaz:
https://doaj.org/article/d23bff0687c54c6580d8f25dd12d3d54
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Laura Palma, Paulo E. L. Parente, Margaux Sambon, Sooyeon Lee, Emma Muiños Lopez, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Development. 150
Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is crucial for the successful generation and application of future therapeutics. Her
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Sophie M. Morgani, Laura Palma, Paulo EL Parente, Sooyeon Lee, Emma Muiños Lopez, Philipp Leucht
Periosteal stem and progenitor cells are pivotal to the growth and lifelong turnover of bone and underpin its capacity to regenerate. Adjusting the potency of this cell population will therefore be critical to the successful generation and applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd359cef106386fa214fe375b1e3048
https://doi.org/10.1101/2022.05.15.492027
https://doi.org/10.1101/2022.05.15.492027
Autor:
Emma Muiños Lopez, Kevin Leclerc, Malissa Ramsukh, Paulo EL Parente, Karan Patel, Carlos J. Aranda, Anna M. Josephson, Lindsey H. Remark, David J. Kirby, Daniel B. Buchalter, Tarik Hadi, Sophie M. Morgani, Bhama Ramkhelawon, Philipp Leucht
Publikováno v:
Bone
Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful
Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor downstream of RAS signaling.Rreb1has been implicated in cancer but little is known about its role in mammalian non-disease states. Here, we found that Rreb1 is ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0479586911989c9bbbae73e9b6d8c3d6
https://doi.org/10.1101/2020.11.12.379578
https://doi.org/10.1101/2020.11.12.379578
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2214
Pluripotent stem cells (PSCs) are the in vitro counterpart of the pluripotent epiblast of the mammalian embryo with the capacity to generate all cell types of the adult organism. During development, the three definitive germ layers are specified and