Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sophie M. C. Gobeil"'
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Autor:
Victoria Stalls, Jared Lindenberger, Sophie M-C. Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Bryan Kraft, Xiaozhi Lu, Robert J Edwards, Amanda Eaton, David C. Montefiori, Wilton Williams, Kevin O. Saunders, Kevin Wiehe, Barton F. Haynes, Priyamvada Acharya
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sub-lineage has gained in proportion relative to BA.1. Because spike (S) protein variations may underlie differences in their pathobiology, here we determine cryoelectron m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37912d5f468cb486bab167fb5e84c33
https://doi.org/10.1101/2022.04.07.487528
https://doi.org/10.1101/2022.04.07.487528
Autor:
Megan Kopp, S. Munir Alam, Sophie M. C. Gobeil, R Parks, Priyamvada Acharya, Zekun Mu, Rory Henderson, Gregory D. Sempowski, Robert J. Edwards, Kartik Manne, Dapeng Li, Kevin O. Saunders, Jordan Sprenz, Katarzyna Janowska, Wilton B. Williams, Margaret Deyton, Xiaozhi Lu, Brian E. Watts, Barton F. Haynes, Thomas H. Oguin, Victoria Stalls, Katayoun Mansouri, David C. Montefiori
Publikováno v:
bioRxiv
Nature structural & molecular biology
Nature Structural & Molecular Biology
Nature structural & molecular biology
Nature Structural & Molecular Biology
The impact of COVID-19 and the urgency to develop a vaccine against the SARS-CoV-2 virus cannot be overstated. The viral fusion spike (S) protein ectodomain is the primary target for vaccine development. Here we report an unexpected cold sensitivity
Autor:
Sophie M-C. Gobeil, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Kartik Manne, Dapeng Li, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katayoun Mansouri, Robert J. Edwards, Gregory D. Sempowski, Kevin O. Saunders, Kevin Wiehe, Wilton Williams, Bette Korber, Barton F. Haynes, Priyamvada Acharya
Publikováno v:
bioRxiv
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor binding domain (RBD) and neutralizing
Autor:
Sophie M.-C. Gobeil, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Kartik Manne, Dapeng Li, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katayoun Mansouri, Robert J. Edwards, Amanda Eaton, David C. Montefiori, Gregory D. Sempowski, Kevin O. Saunders, Kevin Wiehe, Wilton Williams, Bette Korber, Barton F. Haynes, Priyamvada Acharya
Publikováno v:
Molecular cell. 82(11)
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor-binding domain (RBD) and neutralizing
Autor:
Sophie M. C. Gobeil, D. Christopher Cole, William J. Steinbach, Joseph Heitman, Ronald A. Venters, Leonard D. Spicer, Praveen R. Juvvadi, Benjamin G. Bobay
Publikováno v:
Biochem Biophys Res Commun
The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection
Autor:
D. Christopher Cole, William J. Steinbach, Leonard D. Spicer, Benjamin G. Bobay, Praveen R. Juvvadi, Sophie M. C. Gobeil, Ronald A. Venters, Joseph Heitman
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, Vol 12, Iss 6 (2021)
Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting
Publikováno v:
Biomolecular Nmr Assignments
Invasive fungal infections are a leading cause of death in immunocompromised patients and remain difficult to treat since fungal pathogens, like mammals, are eukaryotes and share many orthologous proteins. As a result, current antifungal drugs have l
Autor:
Victoria Stalls, Kartik Manne, Shana McDowell, Kevin Wiehe, Robert Parks, Megan Kopp, Rory Henderson, Katayoun Mansouri, Katarzyna Janowska, Sophie M. C. Gobeil, Priyamvada Acharya, Bette T. Korber, Dapeng Li, Robert J. Edwards, Kevin O. Saunders, Barton F. Haynes
Publikováno v:
bioRxiv
Science
Science
SummaryNew SARS-CoV-2 variants that have accumulated multiple mutations in the spike (S) glycoprotein enable increased transmission and resistance to neutralizing antibodies. Here, we study the antigenic and structural impacts of the S protein mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b568924d33e107b426c6af445a6def1
https://doi.org/10.1101/2021.03.11.435037
https://doi.org/10.1101/2021.03.11.435037
Autor:
Barton F. Haynes, Esther J. Lee, Mark G. Lewis, Laura L. Sutherland, Robert J. Edwards, Kevin O. Saunders, S. Munir Alam, R. Wes Rountree, Mark A. Tomai, Kartik Manne, Priyamvada Acharya, Anyway B. Kapingidza, C. Todd DeMarco, Sophie M. C. Gobeil, Maggie Barr, Robert A. Seder, Matthew Gagne, Robert Parks, Rachel L. Spreng, Dapeng Li, Gregory D. Sempowski, Aja Sanzone, Hanne Leth Andersen, Ralph S. Baric, Christopher B. Fox, Mihai L. Azoitei, Elizabeth Petzold, Thomas N. Denny, Longping V. Tse, Christopher W. Woods, David C. Montefiori, Drew Weissman, Norbert Pardi, Daniel C. Douek, Haiyan Chen, Katayoun Mansouri, David R. Martinez, Ian N. Moore, Trevor Scobey, Thomas H. Oguin, Kevin Wiehe, Madison Berry, Fangping Cai
Publikováno v:
bioRxiv
SUMMARYBetacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7849ac2671cd4a5cdd07c8df6f443fbc
https://doi.org/10.1101/2021.02.17.431492
https://doi.org/10.1101/2021.02.17.431492