Výsledky vyhledávání - "Sophie M-C. Gobeil"

Akademický článek

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Autor: Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer

Publikováno v: mBio, Vol 12, Iss 6 (2021)

ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so e

Externí odkaz: https://doaj.org/article/0963e345cfb74f47bf957fdadaef28c6

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Akademický článek

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm

Externí odkaz: https://doaj.org/article/4b8d65315776423982c1bea6612cead9

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Akademický článek

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

Autor: Sophie M.-C. Gobeil, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Kartik Manne, Victoria Stalls, Megan F. Kopp, Rory Henderson, Robert J. Edwards, Barton F. Haynes, Priyamvada Acharya

Publikováno v: Cell Reports, Vol 34, Iss 2, Pp 108630- (2021)

Summary: The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a low mutation rate, isolates with the D614G substitution in t

Externí odkaz: https://doaj.org/article/efcb6d3fcad74ce58bb8ce3f7be2dd83

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Cold sensitivity of the SARS-CoV-2 spike ectodomain

Publikováno v: bioRxiv
Nature structural & molecular biology
Nature Structural & Molecular Biology

The impact of COVID-19 and the urgency to develop a vaccine against the SARS-CoV-2 virus cannot be overstated. The viral fusion spike (S) protein ectodomain is the primary target for vaccine development. Here we report an unexpected cold sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f639a393fd946e38b873a5d35d5f7fe1
https://doi.org/10.1038/s41594-020-00547-5

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FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus

Autor: Sophie M. C. Gobeil, D. Christopher Cole, William J. Steinbach, Joseph Heitman, Ronald A. Venters, Leonard D. Spicer, Praveen R. Juvvadi, Benjamin G. Bobay

Publikováno v: Biochem Biophys Res Commun

The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5489f68cc99f3b3647acc14d6f487d
https://doi.org/10.1016/j.bbrc.2020.03.062

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Structural diversity of the SARS-CoV-2 Omicron spike

Publikováno v: bioRxiv

Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor binding domain (RBD) and neutralizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34e4d71cf68a8675ed733207c54a227
https://pubmed.ncbi.nlm.nih.gov/35447081

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Structural diversity of the SARS-CoV-2 Omicron spike

Publikováno v: Molecular cell. 82(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6c7cdb0377d874ec5cb47ee4502b6f
https://pubmed.ncbi.nlm.nih.gov/35118469

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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Autor: D. Christopher Cole, William J. Steinbach, Leonard D. Spicer, Benjamin G. Bobay, Praveen R. Juvvadi, Sophie M. C. Gobeil, Ronald A. Venters, Joseph Heitman

Publikováno v: mBio
mBio, Vol 12, Iss 6 (2021)

Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f68f6b54b5064b19d5bea825e321a
http://europepmc.org/articles/PMC8609367

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15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus

Autor: Benjamin G. Bobay, Leonard D. Spicer, Sophie M. C. Gobeil, Ronald A. Venters

Publikováno v: Biomolecular Nmr Assignments

Invasive fungal infections are a leading cause of death in immunocompromised patients and remain difficult to treat since fungal pathogens, like mammals, are eukaryotes and share many orthologous proteins. As a result, current antifungal drugs have l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7b8343fcf9a987a24cd4ab07805281
https://doi.org/10.1007/s12104-019-09878-x

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