Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sophie M Morgani"'
Publikováno v:
eLife, Vol 10 (2021)
Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstream of RAS signaling. Rreb1 has been implicated in cancer and Noonan-like RASopathies. However, little is known about its role in mammalian non-disea
Externí odkaz:
https://doaj.org/article/1a1a503e39c84cdf835b75dbd184cb0b
Autor:
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis
Publikováno v:
eLife, Vol 7 (2018)
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces.
Externí odkaz:
https://doaj.org/article/8eea50c5e0f14b07bca739e2f1420f10
Autor:
Silas Boye Nissen, Marta Perera, Javier Martin Gonzalez, Sophie M Morgani, Mogens H Jensen, Kim Sneppen, Joshua M Brickman, Ala Trusina
Publikováno v:
PLoS Biology, Vol 15, Iss 7, p e2000737 (2017)
Early mammalian development is both highly regulative and self-organizing. It involves the interplay of cell position, predetermined gene regulatory networks, and environmental interactions to generate the physical arrangement of the blastocyst with
Externí odkaz:
https://doaj.org/article/4ca8e980dd604296bab37e5d629be73a
Autor:
Sophie M Morgani, Joshua M Brickman
Publikováno v:
eLife, Vol 2 (2013)
Experiments on the social amoeba Dictyostelium discoideum show that the origins of lineage bias in this system lie in the nutritional history of individual cells. Clues to the molecular basis for this process suggest similar forces may be at work in
Externí odkaz:
https://doaj.org/article/752e829399094691aa7d1ad7b8f15d3c
Autor:
Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental tra
Externí odkaz:
https://doaj.org/article/0d64cab140164afb8b8aaf26ab3db645
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Laura Palma, Paulo E. L. Parente, Margaux Sambon, Sooyeon Lee, Emma Muiños Lopez, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Development. 150
Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is crucial for the successful generation and application of future therapeutics. Her
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Sophie M. Morgani, Laura Palma, Paulo EL Parente, Sooyeon Lee, Emma Muiños Lopez, Philipp Leucht
Periosteal stem and progenitor cells are pivotal to the growth and lifelong turnover of bone and underpin its capacity to regenerate. Adjusting the potency of this cell population will therefore be critical to the successful generation and applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd359cef106386fa214fe375b1e3048
https://doi.org/10.1101/2022.05.15.492027
https://doi.org/10.1101/2022.05.15.492027
Autor:
Emma Muiños Lopez, Kevin Leclerc, Malissa Ramsukh, Paulo EL Parente, Karan Patel, Carlos J. Aranda, Anna M. Josephson, Lindsey H. Remark, David J. Kirby, Daniel B. Buchalter, Tarik Hadi, Sophie M. Morgani, Bhama Ramkhelawon, Philipp Leucht
Publikováno v:
Bone
Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful
Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor downstream of RAS signaling.Rreb1has been implicated in cancer but little is known about its role in mammalian non-disease states. Here, we found that Rreb1 is ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0479586911989c9bbbae73e9b6d8c3d6
https://doi.org/10.1101/2020.11.12.379578
https://doi.org/10.1101/2020.11.12.379578