Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sophie M Morgani"'
Autor:
Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental tra
Externí odkaz:
https://doaj.org/article/0d64cab140164afb8b8aaf26ab3db645
Publikováno v:
Biology Open, Vol 10, Iss 5 (2021)
During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation. At the same time, a small population of pluripotent cells give rise to t
Externí odkaz:
https://doaj.org/article/3a14b8d6b18f4711a71be5eb9505e413
Publikováno v:
eLife, Vol 10 (2021)
Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstream of RAS signaling. Rreb1 has been implicated in cancer and Noonan-like RASopathies. However, little is known about its role in mammalian non-disea
Externí odkaz:
https://doaj.org/article/1a1a503e39c84cdf835b75dbd184cb0b
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Laura Palma, Paulo E. L. Parente, Margaux Sambon, Sooyeon Lee, Emma Muiños Lopez, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Development. 150
Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is crucial for the successful generation and application of future therapeutics. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b827dd431e5362201268ec171cfddecb
https://doi.org/10.1242/dev.201391
https://doi.org/10.1242/dev.201391
Autor:
Javier Martin Gonzalez, Sophie M. Morgani, Robert A. Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch, Joshua M. Brickman
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 177-191 (2016)
Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in eit
Externí odkaz:
https://doaj.org/article/ebe5d83f8ce1449da14f67cbdc1edb8f
Autor:
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis
Publikováno v:
eLife, Vol 7 (2018)
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces.
Externí odkaz:
https://doaj.org/article/8eea50c5e0f14b07bca739e2f1420f10
Autor:
Silas Boye Nissen, Marta Perera, Javier Martin Gonzalez, Sophie M Morgani, Mogens H Jensen, Kim Sneppen, Joshua M Brickman, Ala Trusina
Publikováno v:
PLoS Biology, Vol 15, Iss 7, p e2000737 (2017)
Early mammalian development is both highly regulative and self-organizing. It involves the interplay of cell position, predetermined gene regulatory networks, and environmental interactions to generate the physical arrangement of the blastocyst with
Externí odkaz:
https://doaj.org/article/4ca8e980dd604296bab37e5d629be73a
Autor:
Kevin Leclerc, Lindsey H. Remark, Malissa Ramsukh, Anne Marie Josephson, Sophie M. Morgani, Laura Palma, Paulo EL Parente, Sooyeon Lee, Emma Muiños Lopez, Philipp Leucht
Periosteal stem and progenitor cells are pivotal to the growth and lifelong turnover of bone and underpin its capacity to regenerate. Adjusting the potency of this cell population will therefore be critical to the successful generation and applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd359cef106386fa214fe375b1e3048
https://doi.org/10.1101/2022.05.15.492027
https://doi.org/10.1101/2022.05.15.492027
Autor:
Sophie M. Morgani, Maurice A. Canham, Jennifer Nichols, Alexei A. Sharov, Rosa Portero Migueles, Minoru S.H. Ko, Joshua M. Brickman
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1945-1957 (2013)
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with i
Externí odkaz:
https://doaj.org/article/d23bff0687c54c6580d8f25dd12d3d54
Autor:
Emma Muiños Lopez, Kevin Leclerc, Malissa Ramsukh, Paulo EL Parente, Karan Patel, Carlos J. Aranda, Anna M. Josephson, Lindsey H. Remark, David J. Kirby, Daniel B. Buchalter, Tarik Hadi, Sophie M. Morgani, Bhama Ramkhelawon, Philipp Leucht
Publikováno v:
Bone
Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227f939b0600536604f4b7bf8991ecfb
https://pubmed.ncbi.nlm.nih.gov/34998981
https://pubmed.ncbi.nlm.nih.gov/34998981