Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sophie M Hapak"'
Publikováno v:
Clinical and Experimental Gastroenterology. 15:41-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fff228fdf9a43f035eb6f7885942ef
https://doi.org/10.2147/ceg.s345531
https://doi.org/10.2147/ceg.s345531
Publikováno v:
Trends in Molecular Medicine. 24:615-629
Genome-wide screens, proteomics, and candidate-based approaches have identified numerous genes associated with neuronal regeneration following central nervous system (CNS) injury. Despite significant progress, functional recovery remains a challenge,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb9bb8f7360227b5b2305e137b72a49
https://doi.org/10.1016/j.molmed.2018.05.007
https://doi.org/10.1016/j.molmed.2018.05.007
Publikováno v:
Cellular and Molecular Life Sciences. 75:2735-2761
Polarity is a fundamental feature of cells. Protein complexes, including the PAR3-PAR6-aPKC complex, have conserved roles in establishing polarity across a number of eukaryotic cell types. In neurons, polarity is evident as distinct axonal versus den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b363884615a6e99ccbfd71db662912a
https://doi.org/10.1007/s00018-018-2828-6
https://doi.org/10.1007/s00018-018-2828-6
Publikováno v:
Neuronal Signaling
The atypical Protein Kinase Cs (aPKCs)—PRKCI, PRKCZ and PKMζ—form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs, PKMζ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21739cea34248ab5bdaa1c84cc106405
https://pubmed.ncbi.nlm.nih.gov/32269838
https://pubmed.ncbi.nlm.nih.gov/32269838
Publikováno v:
Current opinion in immunology. 55
Coagulopathies and inflammatory diseases, ostensibly, have distinct underlying molecular bases. Notwithstanding, both are host defense mechanisms to physical injury. In invertebrates, clotting can function directly in anti-pathogen defense. Molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f87cf28f5c6b4c8cb9e60d65a4d45b
https://pubmed.ncbi.nlm.nih.gov/30268838
https://pubmed.ncbi.nlm.nih.gov/30268838
Autor:
Sophie M. Hapak, Paul A. St. John, Irina Y. Maskaykina, Ji Young Kim, Sara S. Parker, Jamie K. Moy, Yael Kusne, Theodore J. Price, Sourav Ghosh, Jean M. Wilson, Katalin M. Gothard, Edward K. Mandell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(35)
Atypical protein kinase C (aPKC) isoforms ζ and λ interact with polarity complex protein Par3 and are evolutionarily conserved regulators of cell polarity. Prkcz encodes aPKC-ζ and PKM-ζ, a truncated, neuron-specific alternative transcript, and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891cbc4bc0db83c4a4e89b1e1dcb11fa
https://pubmed.ncbi.nlm.nih.gov/23940317
https://pubmed.ncbi.nlm.nih.gov/23940317
Autor:
Theodore J. Price, Yael Kusne, Nader Sanai, Emily L. Goldberg, Wade M. Chew, Sourav Ghosh, Irina Y. Maskaykina, Heddwen L. Brooks, Kirsten H. Limesand, Sophie M. Hapak, Sara S. Parker, Janko Nikolich-Zugich
Publikováno v:
Age (Dordrecht, Netherlands). 36(1)
The chronic and systemic administration of rapamycin extends life span in mammals. Rapamycin is a pharmacological inhibitor of mTOR. Metformin also inhibits mTOR signaling but by activating the upstream kinase AMPK. Here we report the effects of chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723961c5a3a71d46c7c6f28d6d20231f
https://pubmed.ncbi.nlm.nih.gov/23949159
https://pubmed.ncbi.nlm.nih.gov/23949159