NQO1 protects obese mice through improvements in glucose and lipid metabolism

Autor: Christine Henke, Kristofer S. Fritz, Andrea Di Francesco, Krystle Kalafut, Myriam Gorospe, Sophie Levan, Joshua D. Preston, Diana M. Willmes, Plácido Navas, Alejandro Martin-Montalvo, Kevin J. Pearson, Rafael de Cabo, Kelsey N. Murt, David Siegel, David Ross, Ahmed Ali, Miguel A. Aon, Michel Bernier, Shyam Biswal, Cole R. Michel, Yingchun Zhang, Alberto Diaz-Ruiz, Youngshim Choi, Margaux R. Ehrlich, Kotb Abdelmohsen, José M. Villalba, Jennifer L. Martindale

Publikováno v: npj Aging Mech. Dis. 6:13 (2020)
NPJ Aging and Mechanisms of Disease
Digital.CSIC. Repositorio Institucional del CSIC
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npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-18 (2020)

Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the

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