An interactive murine single-cell atlas of the lung responses to radiation injury

Autor: Sandra Curras-Alonso, Juliette Soulier, Thomas Defard, Christian Weber, Sophie Heinrich, Hugo Laporte, Sophie Leboucher, Sonia Lameiras, Marie Dutreix, Vincent Favaudon, Florian Massip, Thomas Walter, Florian Mueller, José-Arturo Londoño-Vallejo, Charles Fouillade

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecu

Externí odkaz: https://doaj.org/article/7788259f5ecf40bdbe9d48c2cda857db

Data from FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence

Autor: Vincent Favaudon, Arturo Londoño-Vallejo, Marie Dutreix, Pierre Verrelle, Marc Vooijs, Sylvain Baulande, Mylène Bohec, Hamza Umut Karakurt, Sophie Leboucher, Arnaud Beddok, Sarah Bonnet-Boissinot, Sophie Heinrich, Eddy Quelennec, Lorena Giuranno, Sandra Curras-Alonso, Charles Fouillade

Purpose:One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field. “FLASH” irradiation at very high dose-rate is a new treatment modality that has been reported to spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ed6d7cae488680025a6bef70ead337
https://doi.org/10.1158/1078-0432.c.6528476

Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors

Autor: Rosine Onclercq-Delic, Géraldine Buhagiar-Labarchède, Sophie Leboucher, Thibaut Larcher, Mireille Ledevin, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret

Publikováno v: Cancer Letters. 555:216030

Cytidine deaminase (CDA) catalyzes the deamination of cytidine (C) and deoxycytidine (dC) to uridine and deoxyuridine, respectively. We recently showed that CDA deficiency leads to genomic instability, a hallmark of cancers. We therefore investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58529d6aa9bf50f6ee69b3459c8ce6dc
https://doi.org/10.1016/j.canlet.2022.216030

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Autor: Aleksandr Kostarev, Carsten Janke, Côme Ialy-Radio, Marjorie Whitfield, Luis Alvarez, Sudarshan Gadadhar, Aminata Touré, Sophie Leboucher, Gaia Pigino, An Gong, Jan N. Hansen, Ahmed Ziyyat, Gonzalo Alvarez Viar

Publikováno v: Science
Science, American Association for the Advancement of Science, 2021, 371 (6525), pp.eabd4914. ⟨10.1126/science.abd4914⟩
Science, 2021, 371 (6525), pp.eabd4914. ⟨10.1126/science.abd4914⟩

Glycylation regulates axonemal dyneins Physiological functions of the microtubule cytoskeleton are expected to be regulated by a variety of posttranslational tubulin modifications. For instance, tubulin glycylation is almost exclusively found in cili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec15766c0efe01321f70602fd55a04f
https://hal.archives-ouvertes.fr/hal-03323742/document

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence

Autor: Hamza Umut Karakurt, Charles Fouillade, Mylène Bohec, Sandra Curras-Alonso, Arturo Londoño-Vallejo, Eddy Quelennec, Lorena Giuranno, Sophie Heinrich, Vincent Favaudon, Marie Dutreix, Marc Vooijs, Arnaud Beddok, Sophie Leboucher, Pierre Verrelle, Sarah Bonnet-Boissinot, Sylvain Baulande

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2020, 26 (6), pp.1497-1506. ⟨10.1158/1078-0432.CCR-19-1440⟩
Clinical Cancer Research, American Association for Cancer Research, 2020, ⟨10.1158/1078-0432.CCR-19-1440⟩
Clinical Cancer Research, 26(6), 1497-1506. American Association for Cancer Research Inc.

Purpose: One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field. “FLASH” irradiation at very high dose-rate is a new treatment modality that has been reported to sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee3499eabb360de5c847fc1a080e940
https://hal.archives-ouvertes.fr/hal-03014385