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Autor:
Fell Jay Bradford, John A. Josey, Steven Swallow, Sophie LePogam, Sonal Rajyaguru, Robert Than Hendricks, James F. Blake, John P. Fischer, Stacey Renee Spencer, Vincent Leveque, Isabel Najera, Stengel Peter J
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.