Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sophie L. Gibbings"'
Autor:
Kelsey C. Haist, Sophie L. Gibbings, Jordan Jacobelli, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109589- (2024)
Summary: Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD (gp91phox−/−) versus wild-type (WT) mice, an ex vivo system of
Externí odkaz:
https://doaj.org/article/3319f50980b44809ac3b2750cd5c9663
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLoss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91phox-/- (CGD) mono
Externí odkaz:
https://doaj.org/article/73d155270d1d405cb161babfaf07b083
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Every immune response has accelerators and brakes. Depending on the pathogen or injury, monocytes can play either role, promoting or resolving immunity. Poly I:C, a potent TLR3 ligand, licenses cross-presenting dendritic cells (DC1) to accelerate a r
Externí odkaz:
https://doaj.org/article/9f5088b51ba3444cba8a48d185ad11d5
Autor:
Sonia M. Leach, Sophie L. Gibbings, Anita D. Tewari, Shaikh M. Atif, Brian Vestal, Thomas Danhorn, William J. Janssen, Tor D. Wager, Claudia V. Jakubzick
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108337- (2020)
Summary: The mononuclear phagocyte (MP) system consists of macrophages, monocytes, and dendritic cells (DCs). MP subtypes play distinct functional roles in steady-state and inflammatory conditions. Although murine MPs are well characterized, their pu
Externí odkaz:
https://doaj.org/article/e7c207a5ecc345248500e61a3a47f466
Autor:
Kavita Rawat, Anita Tewari, Xin Li, Arlind B. Mara, William T. King, Sophie L. Gibbings, Chinaza F. Nnam, Fred W. Kolling, Bart N. Lambrecht, Claudia V. Jakubzick
Publikováno v:
The Journal of experimental medicine, 220(6):e20222129. Rockefeller University Press
Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory DCs express this chemokine receptor, it is unclear how monocytes reach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d749985419ea4b5ff9650b1f85118111
https://doi.org/10.1084/jem.20222129
https://doi.org/10.1084/jem.20222129
Autor:
Sophie L. Gibbings, Bradford J. Smith, Peter M. Henson, William J. Janssen, Douglas Curran-Everett, Patrick S. Hume, Claudia Jakubzick, Rubin M. Tuder
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:1209-1217
Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a number of lung diseases. ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cf6b703297f674b9edcfbc6a6b8b814
https://doi.org/10.1164/rccm.201911-2105oc
https://doi.org/10.1164/rccm.201911-2105oc
Autor:
Leila S. Saleh, Luke D. Amer, Brittany J. Thompson, Thomas Danhorn, Jennifer R. Knapp, Sophie L. Gibbings, Stacey Thomas, Lea Barthel, Brian P. O'Connor, William J. Janssen, Scott Alper, Stephanie J. Bryant
Publikováno v:
Adv Healthc Mater
Poly(ethylene glycol) (PEG) hydrogels hold promise for in vivo applications but induce a foreign body response (FBR). While macrophages are key in the FBR, many questions remain. This study investigates temporal changes in the transcriptome of implan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa09de9918a60bf42ee78e3d1ca2574
https://europepmc.org/articles/PMC9081184/
https://europepmc.org/articles/PMC9081184/
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Every immune response has accelerators and brakes. Depending on the pathogen or injury, monocytes can play either role, promoting or resolving immunity. Poly I:C, a potent TLR3 ligand, licenses cross-presenting dendritic cells (DC1) to accelerate a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6841e7e4779069beb09f51508a7e595a
http://europepmc.org/articles/PMC8527167
http://europepmc.org/articles/PMC8527167
Autor:
Ki-Wook Kim, Anastasiia Gainullina, Martin Guilliams, Lim Sheau Yng, Charlotte L. Scott, Alexey Sergushichev, Maxim N. Artyomov, Li-Hao Huang, Tyng-An Zhou, Jun Wu, Christophe Benoist, Peter See, Karen Krchma, Gwendalyn J. Randolph, Claudia Jakubzick, Vipin Narang, Geetika Bajpai, Florent Ginhoux, Helena Paidassi, Sophie L. Gibbings, Elena Tomasello, Emmanuel L. Gautier, Andrew Kent, Karine Crozat, Barbara Maier, Stephanie Vargas Aguilar, Peter L. Wang, Jigar V. Desai, Lucie Poupel, Ivan Dzhagalov, Marc Dalod, Kyunghee Choi, J. Magarian Blander, Regine J. Dress, Kumba Seddu, Sebastien This, Helena Todorov, Michail S. Lionakis, Veronique Angeli, Kory J. Lavine, Michael H. Sieweke, Baosen Jia, Sébastien Dussaud, Miriam Merad
We dissect metabolic variability of mononuclear phagocyte (MNP) subpopulations across different tissues through integrative analysis of three large scale datasets. Specifically, we introduce ImmGen MNP Open Source dataset that profiled 337 samples an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0110b6038049c5ddb3c0da02a21730
https://doi.org/10.1101/2020.07.15.204388
https://doi.org/10.1101/2020.07.15.204388
Autor:
Brian Vestal, Anita Tewari, Thomas Danhorn, Tor D. Wager, Shaikh M. Atif, William J. Janssen, Claudia Jakubzick, Sophie L. Gibbings, Sonia M. Leach
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108337-(2020)
Cell reports
Cell reports
SUMMARY The mononuclear phagocyte (MP) system consists of macrophages, monocytes, and dendritic cells (DCs). MP subtypes play distinct functional roles in steady-state and inflammatory conditions. Although murine MPs are well characterized, their pul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6176b3b0ae3046d3baaf68881609536