Výsledky vyhledávání - "Sophie L. Farrow"

Akademický článek

Identification of 27 allele-specific regulatory variants in Parkinson’s disease using a massively parallel reporter assay

Autor: Sophie L. Farrow, Sreemol Gokuladhas, William Schierding, Michael Pudjihartono, Jo K. Perry, Antony A. Cooper, Justin M. O’Sullivan

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)

Abstract Genome wide association studies (GWAS) have identified a number of genomic loci that are associated with Parkinson’s disease (PD) risk. However, the majority of these variants lie in non-coding regions, and thus the mechanisms by which the

Externí odkaz: https://doaj.org/article/777c62e53bcb4a74b6e99d11f4201189

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Akademický článek

Redefining the hypotheses driving Parkinson’s diseases research

Autor: Sophie L. Farrow, Antony A. Cooper, Justin M. O’Sullivan

Publikováno v: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-7 (2022)

Abstract Parkinson’s disease (PD) research has largely focused on the disease as a single entity centred on the development of neuronal pathology within the central nervous system. However, there is growing recognition that PD is not a single entit

Externí odkaz: https://doaj.org/article/7712410501b9492f88d330ad36f38a4e

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Akademický článek

Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity

Autor: Daniel Ho, William Schierding, Sophie L. Farrow, Antony A. Cooper, Andreas W. Kempa-Liehr, Justin M. O’Sullivan

Publikováno v: Frontiers in Genetics, Vol 12 (2022)

Parkinson’s disease (PD) is a complex neurodegenerative disease with a range of causes and clinical presentations. Over 76 genetic loci (comprising 90 SNPs) have been associated with PD by the most recent GWAS meta-analysis. Most of these PD-associ

Externí odkaz: https://doaj.org/article/1baa78bf6e904c66ab792fe373977d8e

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Establishing gene regulatory networks from Parkinson’s disease risk loci

Autor: Sophie L Farrow, William Schierding, Sreemol Gokuladhas, Evgeniia Golovina, Tayaza Fadason, Antony A Cooper, Justin M O’Sullivan

Publikováno v: Brain. 145:2422-2435

The latest meta-analysis of genome-wide association studies identified 90 independent variants across 78 genomic regions associated with Parkinson’s disease, yet the mechanisms by which these variants influence the development of the disease remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a107b490581653f681cd6031162e77
https://doi.org/10.1093/brain/awac022

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Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity

Autor: Daniel Ho, William Schierding, Sophie L. Farrow, Antony A. Cooper, Andreas W. Kempa-Liehr, Justin M. O’Sullivan

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2022)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1571933707db087703d1832b35fb080
https://pubmed.ncbi.nlm.nih.gov/35047012

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Redefining the hypotheses driving Parkinson's diseases research

Autor: Sophie L, Farrow, Antony A, Cooper, Justin M, O'Sullivan

Publikováno v: NPJ Parkinson's disease. 8(1)

Parkinson's disease (PD) research has largely focused on the disease as a single entity centred on the development of neuronal pathology within the central nervous system. However, there is growing recognition that PD is not a single entity but inste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e23ea06df1df426bada9dfb3f831a53
https://pubmed.ncbi.nlm.nih.gov/35440633

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