Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sophie L. Allen"'
Autor:
Thomas Nicholson, Amritpal Dhaliwal, Jonathan I. Quinlan, Sophie L. Allen, Felicity R. Williams, Jon Hazeldine, Kirsty C. McGee, Jack Sullivan, Leigh Breen, Ahmed M. Elsharkawy, Matthew J. Armstrong, Simon W. Jones, Carolyn A. Greig, Janet M. Lord
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1667-1681 (2024)
Abstract Patients with chronic liver disease (CLD) often present with significant frailty, sarcopenia, and impaired immune function. However, the mechanisms driving the development of these age-related phenotypes are not fully understood. To determin
Externí odkaz:
https://doaj.org/article/0915fd3c614042489026aea03cbe9dbe
Autor:
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Sophie L. Allen, Surabhi Choudhary, Alex Rowlands, Leigh Breen, Gareth G. Lavery, Janet M. Lord, Ahmed M. Elsharkawy, Matthew J. Armstrong, Carolyn A. Greig
Publikováno v:
Experimental Physiology, Vol 108, Iss 8, Pp 1066-1079 (2023)
Abstract Sarcopenia is associated with reduced quality of life and increased mortality in patients with end stage liver disease (ESLD). Historically, sarcopenia identification in ESLD utilised L3 skeletal muscle index (SMI). There are few data on mus
Externí odkaz:
https://doaj.org/article/4246730362f141029109dfd801eee9a9
Autor:
Amritpal Dhaliwal, Felicity R. Williams, Jonathan I. Quinlan, Sophie L. Allen, Carolyn Greig, Andrew Filer, Karim Raza, Subrata Ghosh, Gareth G. Lavery, Philip N. Newsome, Surabhi Choudhary, Leigh Breen, Matthew J. Armstrong, Ahmed M. Elsharkawy, Janet M. Lord
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background Several chronic inflammatory diseases co-exist with and accelerate sarcopenia (reduction in muscle strength, function and mass) and negatively impact on both morbidity and mortality. There is currently limited research on the exte
Externí odkaz:
https://doaj.org/article/0f4284fb931d4db28a0c4e7ac2a37607
Autor:
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity Williams, Sophie L. Allen, Leigh Breen, Carolyn A. Greig, Janet M. Lord, Matthew J. Armstrong, Ahmed M. Elsharkawy
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
IntroductionSarcopenia is present in many chronic disease states including decompensated end stage liver disease (ESLD) and non-cirrhotic non-alcoholic fatty liver disease (NAFLD). Sarcopenia in ESLD can negatively impact quality of life and increase
Externí odkaz:
https://doaj.org/article/b274a924935b4433a5327d4e0033e2de
Autor:
Sophie L. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen
Publikováno v:
Cells, Vol 11, Iss 7, p 1098 (2022)
Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease. C2C12 myotub
Externí odkaz:
https://doaj.org/article/d7df7ae34fcb440ab7482dd7ac5fbac2
In vitro models provide an important platform for the investigation of cellular growth and atrophy to inform, or extend mechanistic insights from, logistically challenging in vivo trials. Although these models allow for the identification of candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1288a660f050686a8dfacac41606fbf4
https://figshare.com/articles/journal_contribution/Improving_physiological_relevance_of_cell_culture_the_possibilities_considerations_and_future_directions_of_the_ex_vivo_coculture_model/22099811
https://figshare.com/articles/journal_contribution/Improving_physiological_relevance_of_cell_culture_the_possibilities_considerations_and_future_directions_of_the_ex_vivo_coculture_model/22099811
Autor:
Felicity R Williams, Jonathan I Quinlan, Amritpal Dhaliwal, Alex Rowlands, Sophie L Allen, Leigh Breen, Carolyn Greig, Ahmed Elsharkawy, Janet M Lord, Matthew J Armstrong
Publikováno v:
Abstracts.
Autor:
Sophie L Allen, Gareth G. Lavery, Leigh Breen, Janet M. Lord, Ryan N. Marshall, Sophie J Edwards
Publikováno v:
American Journal of Physiology-Cell Physiology. 321:C26-C37
In vitro models of muscle aging are useful for understanding mechanisms of age-related muscle loss and aiding the development of targeted therapies. To investigate mechanisms of age-related muscle loss in vitro utilizing ex vivo human serum, fasted b
Autor:
Sophie L Allen, Gareth G. Lavery, Leigh Breen, Carolyn A. Greig, Ahmed M. Elsharkawy, Jonathan I. Quinlan, Janet M. Lord, Amritpal Dhaliwal, Matthew J. Armstrong
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Sarcopenia, a condition of low muscle mass, quality, and strength, is commonly found in patients with cirrhosis and is associated with adverse clinical outcomes including reduction in quality of life, increased mortality, and posttransplant complicat
Autor:
Paul T. Morgan, Sophie J Edwards, Sophie L Allen, Jonathan I. Quinlan, Ryan N. Marshall, Dane O Harris, Leigh Breen
Publikováno v:
The Journal of nutrition. 151(7)
BACKGROUND There is much debate regarding the source/quality of dietary proteins in supporting indices of skeletal muscle anabolism. OBJECTIVE We performed a systematic review and meta-analysis to determine the effect of protein source/quality on acu