Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sophie Koutouzov"'
Autor:
Dominique Emilie, Alexis Mathian, Bernard Bizzini, Sophie Koutouzov, Hélène Le Buanec, Patrick Larcier, Zahir Amoura, Robert C. Gallo, Daniel Zagury, Roger M. Burnett, Armand Bensussan, Gabriel Peltre
Publikováno v:
Proceedings of the National Academy of Sciences. 106:5294-5299
A major involvement of IFNα in the etiopathogenesis of systemic lupus erythematosus has been suggested by clinical observations, including the increase of serum levels of this cytokine in patients with active disease. Supporting this hypothesis, we
Publikováno v:
European Journal of Immunology. 30:3271-3280
The association of anti-nuclear antigen (ANA) and anti-cardiolipin (CL) antibodies is often observed during systemic lupus erythematosus (SLE) or the primary anti-phospholipid syndrome, thereby raising the possibility of a relationship between these
Publikováno v:
Current Opinion in Rheumatology. 12:369-373
Nucleosomes play a central role in the antinuclear antibody response in lupus. Lupus anti-dsDNA and antihistone antibodies directed toward nucleosomes belong together with nucleosome-specific antibodies, to a broad antinucleosome antibody family. Bes
Autor:
Isabelle Amoura, Lucile Musset, Patrice Cacoub, Jean-Charles Piette, Zahir Amoura, Henri Chabre, Jean-François Bach, Sophie Koutouzov
Publikováno v:
Arthritis & Rheumatism. 43:76-84
Objective To study the frequency and disease specificity of antinucleosome antibody reactivity in diverse connective tissue diseases (CTD), and to determine factors, such as antibody subclass, that may influence the pathogenicity of these antibodies
Publikováno v:
Arthritis & Rheumatism. 42:833-843
Publikováno v:
Journal of Leukocyte Biology. 64:774-780
The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in p
Autor:
Henri Chabre, Jean-François Bach, Fabien Jovelin, Dan Eilat, Danièle Gilbert, Zahir Amoura, Gustavo Mostoslavsky, Sophie Koutouzov
Publikováno v:
European Journal of Immunology. 28:3411-3422
In systemic lupus erythematosus, the nucleosome assumes a central role in the autoimmune response to self antigens. To gain insight into the etiology and pathogenesis of anti-nucleosome antibodies (Ab), we analyzed a panel of six IgG-secreting hybrid
Publikováno v:
Journal of Autoimmunity. 11:19-27
Increasing evidence suggests that immune complexes made of anti-nuclear antibodies bound to nucleosomes released from dead cells play an important role in the pathogenesis of lupus nephritis. However, the nature and composition of apoptotic nucleosom
Autor:
Patrice Cacoub, Bertrand Wechsler, Henri Chabre, Jean-François Bach, Jean-Charles Piette, Sophie Koutouzov, Zahir Amoura, Thomas Papo
Publikováno v:
Arthritis & Rheumatism. 40:2217-2225
Objective. To assess nucleosome plasma levels in patients with systemic lupus erythematosus (SLE) and to study the correlations with serum antinucleosome, anti-double-stranded DNA (anti-dsDNA), and antihistone antibody activities, as well as with dis
Publikováno v:
Annals of the New York Academy of Sciences. 815:327-330