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pro vyhledávání: '"Sophie Ketchen"'
Autor:
Caroline Seiler, Amy K. Stainthorp, Sophie Ketchen, Christopher M. Jones, Kate Marks, Philip Quirke, John E. Ladbury
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.
Externí odkaz:
https://doaj.org/article/cfc96b6f633f437e925d3d36fc562c13
Autor:
Caroline Seiler, Amy K. Stainthorp, Sophie Ketchen, Christopher M. Jones, Kate Marks, Philip Quirke, John E. Ladbury
Publikováno v:
Communications biology. 5(1)
Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway. This is initiated on recruitment of Grb2, as part of a Grb2-Sos complex, to an up-regulated receptor tyr