Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

Autor: Philip M. Kubara, Aurélie Studeny, Sophie Kernéis-Golsteyn, Laurent Meijer, Roy M. Golsteyn, Brittany B. Lanser

Publikováno v: Biochemical Journal

In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ce6f65b68f0615eee04df2d1069ff2
https://doi.org/10.1042/bj20120385

Human BAHD1 promotes heterochromatic gene silencing

Autor: Jacob S. Seeler, Jean Feunteun, Béatrice Regnault, Morwenna Leguillou, Pascale Cossart, Hélène Bierne, Christian Muchardt, To Nam Tham, Anne Dumay, Eric Batsché, Sophie Kernéis-Golsteyn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (33), pp.13826-31. ⟨10.1073/pnas.0901259106⟩
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (33), pp.13826-31. ⟨10.1073/pnas.0901259106⟩

Gene silencing via heterochromatin formation plays a major role in cell differentiation and maintenance of homeostasis. Here we report the identification and characterization of a novel heterochromatinization factor in vertebrates, bromo adjacent hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2335f47ddc7ab5675cb09c1622a99b09
https://doi.org/10.1073/pnas.0901259106

Biofilm formation by saprophytic and pathogenic leptospires

Autor: Paula Ristow, Sophie Kernéis, Marie-Christine Prévost, Christine Schmitt, Mathieu Picardeau, Walter Lilenbaum, Pascale Bourhy

Publikováno v: Microbiology. 154:1309-1317

Leptospires exist as saprophytic organisms that are aquatic or as pathogens that are able to survive in water. Leptospirosis is transmitted to humans through environmental surface waters contaminated by the urine of mammals, usually rodents, which ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3126b9d5c29f87157fcb2f2057dc97
https://doi.org/10.1099/mic.0.2007/014746-0

Lymphoepithelial Interactions Trigger Specific Regulation of Gene Expression in the M Cell-Containing Follicle-Associated Epithelium of Peyer’s Patches

Autor: Marcelle Bens, Anna Bogdanova, Sophie Kernéis, Sophia El Bahi, Elise Caliot, Axel Kahn, Alain Vandewalle, Eric Pringault

Publikováno v: The Journal of Immunology. 168:3713-3720

In the intestine, the follicle-associated epithelium (FAE) of Peyer’s patches (PP) performs Ag sampling as the first step in developing immune responses. Depending on the species, this epithelium contains 10–50% of M cells, which act as regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b3c13d47d11fe1f70497fe1f26088d
https://doi.org/10.4049/jimmunol.168.8.3713

Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update

Autor: Eric Pringault, Elise Caliot, Hiltrud Stubbe, Anna Bogdanova, Sophie Kernéis, Jean-Pierre Kraehenbuhl

Publikováno v: Microbes and Infection. 2:1119-1124

Peyer's patch lymphocytes cocultured with Caco-2 cells trigger the phenotypic conversion of enterocytes into cells that express morphological and functional M-cell properties. We report a technical update for setting up this model, which will enable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ff1ae2d0b778892da2fd08b873c0d1
https://doi.org/10.1016/s1286-4579(00)01266-1