Výsledky vyhledávání - "Sophie Kerlan-Candon"

HLA-DRB1 gene transcripts in rheumatoid arthritis

Autor: B. Combe, J. F. Eliaou, Sophie Kerlan-Candon, V. Pinet, J. Clot, R. Vincent

Publikováno v: Clinical and Experimental Immunology. 124:142-149

SUMMARYSusceptibility to rheumatoid arthritis (RA) is associated with defined HLA-DRB1 alleles. However the molecular basis of this association is not known. Peculiarities in the expression of disease-linked DRB1 alleles could be involved since in he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5634cac8e3d6a0428f54f26704486fd
https://doi.org/10.1046/j.1365-2249.2001.01498.x

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Specific overexpression of rheumatoid arthritis-associated HLA-DR alleles and presentation of low-affinity peptides

Autor: Sophie Kerlan-Candon, Bernard Combe, Jean-François Eliaou, Valérie Pinet, Pascale Louis-Plence, Agnes Wiedemann, Jacques Clot

Publikováno v: Arthritis and Rheumatism
Arthritis and Rheumatism, Wiley, 2001, 44 (6), pp.1281-1292. ⟨10.1002/1529-0131(200106)44:63.0.CO;2-2⟩

Objective To compare levels of HLA–DR expression in rheumatoid arthritis (RA) patients and healthy controls for whom an ordered expression according to the DR alleles is demonstrated and to test the functional consequences of this expression on pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9601ad7c7dbb1cdbf5a205f04914fa
https://hal.inrae.fr/hal-02676538

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The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism

Autor: Jean-François Eliaou, Bernard Combe, Jacques Morel, Jacques Clot, Pascale Louis-Plence, Sophie Kerlan-Candon, Valérie Pinet

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 165(9)

HLA-DM molecule, a class II-like heterodimer, is a critical factor of HLA class II-dependent Ag presentation. It acts as a molecular chaperone and also functions as a peptide editor favoring the presentation of high-stability peptides. Thus, it appea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80bb973d060de482801a47b215bb58d
https://pubmed.ncbi.nlm.nih.gov/11046010

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Detection of antigen receptor gene rearrangements in lymphoproliferative malignancies by fluorescent polymerase chain reaction

Autor: Jean-François Eliaou, Marie-Paule Lefranc, Jacques Clot, Z. Soua, Sophie Kerlan-Candon

Publikováno v: Tissue antigens. 51(1)

Monoclonal rearrangements of antigen receptor genes in lymphoproliferative diseases are characterized by the specific sequence and the length of their junctional region, which can be used as markers of the proliferating clone. PCR techniques have gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a213aa4b24b8a78c13f55620e1adfd6e
https://pubmed.ncbi.nlm.nih.gov/9459500

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Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution

Autor: Valérie Pinet, Sophie Kerlan-Candon, Jacques Clot, R. Vincent, Pascale Louis, Jean-François Eliaou

Publikováno v: Immunogenetics. 38(1)

Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d9da9544862aeed12286820389e3e
https://pubmed.ncbi.nlm.nih.gov/8462990

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