Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sophie J. Farrar"'
Autor:
Paul J. Whiting, Dalip J. S. Sirinathsinghji, Keith A. Wafford, Robert P. Heavens, Smith David W, Louise Hewson, N. Brown, Michael Rigby, B. Le Bourdelles, Ruth M. McKernan, Timothy P. Bonnert, Sophie J. Farrar
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9891-9896
γ-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b515042ed73c06d7f3a886c991b16e4
https://doi.org/10.1073/pnas.96.17.9891
https://doi.org/10.1073/pnas.96.17.9891
Publikováno v:
Molecular Pharmacology. 56:110-115
Pharmacological study of rat thalamic gamma-aminobutyric acidA (GABAA) receptors revealed the presence of two distinct populations, namely, diazepam-sensitive and diazepam-insensitive [3H]Ro15-4513 binding sites accounting for 94 +/- 2% (1339 +/- 253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15735f47fd31ece8008204b0afb86d5d
https://doi.org/10.1124/mol.56.1.110
https://doi.org/10.1124/mol.56.1.110
Autor:
Smith David W, Louise Hewson, Robert P. Heavens, Paul J. Whiting, Sally A. Thompson, Ruth M. McKernan, Dalip J. S. Sirinathsinghji, Beatrice Le Bourdelles, Sophie J. Farrar, Keith A. Wafford, Michael Rigby, Timothy P. Bonnert
Publikováno v:
Annals of the New York Academy of Sciences. 868:645-653
Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter gamma-aminobutyric acid (GABA), which, upon binding to its receptor, leads to opening of the intrinsic ion channel, allowing chloride to enter the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8cf4c3288064ab5716baeaeb937861
https://doi.org/10.1111/j.1749-6632.1999.tb11341.x
https://doi.org/10.1111/j.1749-6632.1999.tb11341.x
Publikováno v:
Journal of Biological Chemistry. 274:10100-10104
We have developed a method to determine the stoichiometry of subunits within an oligomeric cell surface receptor using fluorescently tagged antibodies to the individual subunits and measuring energy transfer between them. Anti-c-Myc monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c98519df5563eacc9ce8b0c8687639
https://doi.org/10.1074/jbc.274.15.10100
https://doi.org/10.1074/jbc.274.15.10100
Autor:
Ian Collins, F. Emms, Sophie J. Farrar, Ruth M. McKernan, K Quirk, Howard B. Broughton, Ayodeji Asuni
Publikováno v:
Molecular Pharmacology. 54:33-43
Photoincorporation of ligands into the benzodiazepine site of native gamma-aminobutyric acidA (GABAA) receptors provides useful information about the nature of the benzodiazepine (BZ) binding site. Photoincorporation of flunitrazepam into a single po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b875b85e0c08ab405ca74347d12f482d
https://doi.org/10.1124/mol.54.1.33
https://doi.org/10.1124/mol.54.1.33
Autor:
Alison J. Macaulay, C.I. Ragan, Cyrille Sur, David S. Reynolds, George R. Marshall, John R. Atack, Ruth M. McKernan, G. R. Dawson, Kevin W. Moore, Paul J. Whiting, Linda J. Bristow, Owain W. Howell, Keith A. Wafford, N. Brown, Pushpinder Ferris, Sophie J. Farrar, J Myers, G.P. Cook, Leslie J. Street, Castro Jl, Robert W. Carling, L Garrett, Thomas W. Rosahl
Inhibitory neurotransmission in the brain is largely mediated by GABA(A) receptors. Potentiation of GABA receptor activation through an allosteric benzodiazepine (BZ) site produces the sedative, anxiolytic, muscle relaxant, anticonvulsant and cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d523e55b2d3d7d9e472cf1e002f543c
https://cronfa.swan.ac.uk/Record/cronfa16591
https://cronfa.swan.ac.uk/Record/cronfa16591
