Short-term step reduction reduces citrate synthase activity without altering skeletal muscle markers of oxidative metabolism or insulin-mediated signaling in young males

Autor: Leigh Breen, Paul T. Morgan, Brandon J. Shad, Gareth A. Wallis, Sophie J Edwards, Ryan N. Marshall

Publikováno v: Journal of Applied Physiology. 131:1653-1662

Mitochondria are critical to skeletal muscle contractile function and metabolic health. Short-term periods of step reduction (SR) are associated with alterations in muscle protein turnover and mass. However, the effects of SR on mitochondrial metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850c8ee8a27877b2c7f9a7f763ab7fa5
https://doi.org/10.1152/japplphysiol.00650.2021

The effect of short‐term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

Autor: Sophie J Edwards, Matthew S. Brook, Leigh Breen, Konstantinos N. Manolopoulos, Nima Gharahdaghi, Alison Rushton, Paul T. Morgan, Andrew Philp, Yasir S Elhassan, Kenneth Smith, Philip J. Atherton, Benoit Smeuninx, Elizabeth Sapey

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 1, Pp 52-69 (2021)
Journal of Cachexia, Sarcopenia and Muscle

Background Poor recovery from periods of disuse accelerates age‐related muscle loss, predisposing individuals to the development of secondary adverse health outcomes. Exercise prior to disuse (prehabilitation) may prevent muscle deterioration durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24333b6d6fdbf085a819d6c1b03103c9
https://doi.org/10.1002/jcsm.12661

(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells

Autor: Sophie J Edwards, Steven Carter, Thomas Nicholson, Sophie Louise Allen, Paul T Morgan, Simon Wyn Jones, Catarina Rendeiro, Leigh Breen

Publikováno v: The Journal of Nutritional Biochemistry. 110:109150

Cocoa flavanols have been shown to improve muscle function and may offer a novel approach to protect against muscle atrophy. Hippuric acid (HA) is a colonic metabolite of (-)-epicatechin (EPI), the primary bioactive compound of cocoa, and may be resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9898dcd212b8421d321edd3dd2e137da
https://doi.org/10.1016/j.jnutbio.2022.109150

High-dose leucine supplementation does not prevent muscle atrophy or strength loss over 7 days of immobilization in healthy young males

Autor: Molly Perkins, Jill Ramsay, James McKendry, Yusuke Nishimura, Leigh Breen, Dan Luo, Benoit Smeuninx, Sophie J Edwards, Ryan N. Marshall, Sophie Joanisse, Andrew Philp

Publikováno v: The American journal of clinical nutrition. 112(5)

BACKGROUND Unavoidable periods of disuse lead to muscle atrophy and functional decline. Preventing such declines can reduce the risk of re-injury and improve recovery of normal physiological functioning. OBJECTIVES We aimed to determine the effective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba31789cc6d708c332f194ae754d106
https://pubmed.ncbi.nlm.nih.gov/32910813

Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n-Alkyl Substitution

Autor: Vítor Félix, Sophie J. Edwards, Igor Marques, Christopher M. Dias, Robert A. Tromans, Anthony P. Davis, Nicholas R. Lees, Hennie Valkenier

Publikováno v: Chemistry, 22 (6
Chemistry (Weinheim an Der Bergstrasse, Germany)
Edwards, S J, Marques, I, Dias, C M, Tromans, R A, Lees, N R, Félix, V, Valkenier, H & Davis, A P 2016, ' Tilting and Tumbling in Transmembrane Anion Carriers : Activity Tuning through n-Alkyl Substitution ', Chemistry-A European Journal, vol. 22, no. 6, pp. 2004-2011 . https://doi.org/10.1002/chem.201504057
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Anion transport by synthetic carriers (anionophores) holds promise for medical applications, especially the treatment of cystic fibrosis. Among the factors which determine carrier activity, the size and disposition of alkyl groups is proving remarkab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea6f6ca13cac1ea27d387bb8482732e
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/227325