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Perforin-like proteins (PLPs) play key roles in the mechanisms associated with parasitic disease caused by apicomplexans such as Plasmodium (malaria) and Toxoplasma. The T. gondii PLP1 (TgPLP1) mediates tachyzoite egress from cells, while the five Pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b79ff33cc61d955257f73d0edb86bab
http://wrap.warwick.ac.uk/166100/1/1-s2.0-S0022283622002224-main.pdf
http://wrap.warwick.ac.uk/166100/1/1-s2.0-S0022283622002224-main.pdf
Autor:
Gregor Anderluh, Fangfang Bai, Xiulian Yu, Fang Jiao, Lucy Ginger, Robert J.C. Gilbert, Peijun Zhang, Saša Aden, George P. Munson, D. Karia, Simon Scheuring, Vojtěch Pražák, Tao Ni, Sophie I. Williams, Phillip J. Stansfeld
Publikováno v:
Science Advances
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.
Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, f
Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77133c575a27139795195571d819cc2d
http://wrap.warwick.ac.uk/129547/7/WRAP-structure-mechanism-bactericidal-mammalian-ancient-immunity-Stansfeld-2020.pdf
http://wrap.warwick.ac.uk/129547/7/WRAP-structure-mechanism-bactericidal-mammalian-ancient-immunity-Stansfeld-2020.pdf