Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sophie I. Hamstra"'
Autor:
Riley E.G. Cleverdon, Jessica L. Braun, Mia S. Geromella, Kennedy C. Whitley, Daniel M. Marko, Sophie I. Hamstra, Brian D. Roy, Rebecca E.K. MacPherson, Val A. Fajardo
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104972- (2022)
Summary: The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in
Externí odkaz:
https://doaj.org/article/50106664f0bf4e4cadafde9a1a5cf723
Autor:
Jessica L. Braun, Holt N. Messner, Riley E. G. Cleverdon, Ryan W. Baranowski, Sophie I. Hamstra, Mia S. Geromella, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) restores intracellular Ca2+ ([Ca2+]i) to resting levels after muscle contraction, ultimately eliciting relaxation. SERCA pumps are highly susceptible to tyrosine (T)‐nitration, impairing
Externí odkaz:
https://doaj.org/article/031c24bbc2354d519fa7a191f0b7a432
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 10, Pp 579-586 (2020)
Abstract Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the past 25 years, researchers have uncovered NNAT in other tissues; notably, the hypotha
Externí odkaz:
https://doaj.org/article/a4d84decad0746559eb60bab9f834107
Autor:
Kennedy C. Whitley, Sophie I. Hamstra, Ryan W. Baranowski, Colton J. F. Watson, Rebecca E. K. MacPherson, Adam J. MacNeil, Brian D. Roy, Rene Vandenboom, Val A. Fajardo
Publikováno v:
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Abstract Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increase
Externí odkaz:
https://doaj.org/article/6689be618e60477c9bb477efb50dd6cb
Publikováno v:
Physiological Reports, Vol 7, Iss 16, Pp n/a-n/a (2019)
Abstract The sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by phospholamban (PLN
Externí odkaz:
https://doaj.org/article/79803d8c12d340db84615937bae1deba
Autor:
Nigel Kurgan, Kennedy C. Whitley, Lucas A. Maddalena, Fereshteh Moradi, Joshua Stoikos, Sophie I. Hamstra, Elizabeth A. Rubie, Megha Kumar, Brian D. Roy, James R. Woodgett, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Cells, Vol 8, Iss 11, p 1340 (2019)
Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ competition and increased Ser21 (
Externí odkaz:
https://doaj.org/article/dc36e0636c20424e8b1944f2b723ce52
Autor:
Rachel K. Fenech, Sophie I. Hamstra, Michael S. Finch, Chantal R. Ryan, Daniel M. Marko, Brian D. Roy, Val A. Fajardo, Rebecca E.K. MacPherson
Publikováno v:
Journal of Alzheimer's disease : JAD.
Background: Lithium, a commonly used treatment for bipolar disorder, has been shown to have neuroprotective effects for other conditions including Alzheimer’s disease via the inhibition of the enzyme glycogen synthase kinase-3 (GSK3). However, dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566ef7dddd8813040934e3a22876db4a
https://pubmed.ncbi.nlm.nih.gov/36463453
https://pubmed.ncbi.nlm.nih.gov/36463453
Autor:
Mia S, Geromella, Chantal R, Ryan, Jessica L, Braun, Michael S, Finch, Lucas A, Maddalena, Olivia, Bagshaw, Briana L, Hockey, Fereshteh, Moradi, Rachel K, Fenech, Jisook, Ryoo, Daniel M, Marko, Roopan, Dhaliwal, Jake, Sweezey-Munroe, Sophie I, Hamstra, Georgina, Gardner, Sebastian, Silvera, Rene, Vandenboom, Brian D, Roy, Jeffrey A, Stuart, Rebecca E K, MacPherson, Val A, Fajardo
Publikováno v:
The Journal of biological chemistry. 298(11)
Sarco(endo)plasmic reticulum Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7819e39b049f7a1c198135e82039e14e
https://pubmed.ncbi.nlm.nih.gov/36209826
https://pubmed.ncbi.nlm.nih.gov/36209826
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 10, Pp 579-586 (2020)
FASEB BioAdvances
FASEB BioAdvances
Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the past 25 years, researchers have uncovered NNAT in other tissues; notably, the hypothalamus, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be913e36d6e75a67d032e37f777829f9
https://doaj.org/article/a4d84decad0746559eb60bab9f834107
https://doaj.org/article/a4d84decad0746559eb60bab9f834107
Autor:
Nigel Kurgan, Holt N. Messner, Val A. Fajardo, Kennedy C. Whitley, Jessica L. Braun, Ryan W. Baranowski, Sophie I. Hamstra
Publikováno v:
American Journal of Physiology-Cell Physiology. 319:C694-C699
Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout the lifespan. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount to cardiac Ca2+ regulation, and it is well established that SERCA dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c7d74cafa2b155d998b40e65856723
https://doi.org/10.1152/ajpcell.00318.2020
https://doi.org/10.1152/ajpcell.00318.2020