Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sophie I Candille"'
Autor:
Sandra Beleza, Nicholas A Johnson, Sophie I Candille, Devin M Absher, Marc A Coram, Jailson Lopes, Joana Campos, Isabel Inês Araújo, Tovi M Anderson, Bjarni J Vilhjálmsson, Magnus Nordborg, António Correia E Silva, Mark D Shriver, Jorge Rocha, Gregory S Barsh, Hua Tang
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003372 (2013)
Variation in human skin and eye color is substantial and especially apparent in admixed populations, yet the underlying genetic architecture is poorly understood because most genome-wide studies are based on individuals of European ancestry. We study
Externí odkaz:
https://doaj.org/article/0e3976d7638744a5b3a94336e238d31b
Autor:
Sophie I Candille, Devin M Absher, Sandra Beleza, Marc Bauchet, Brian McEvoy, Nanibaa' A Garrison, Jun Z Li, Richard M Myers, Gregory S Barsh, Hua Tang, Mark D Shriver
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48294 (2012)
Pigmentation of the skin, hair, and eyes varies both within and between human populations. Identifying the genes and alleles underlying this variation has been the goal of many candidate gene and several genome-wide association studies (GWAS). Most G
Externí odkaz:
https://doaj.org/article/7584e078008d4990a7bd4e728925edd4
Autor:
Sophie I Candille, Catherine D Van Raamsdonk, Changyou Chen, Sanne Kuijper, Yanru Chen-Tsai, Andreas Russ, Frits Meijlink, Gregory S Barsh
Publikováno v:
PLoS Biology, Vol 2, Iss 1, p E3 (2004)
Many members of the animal kingdom display coat or skin color differences along their dorsoventral axis. To determine the mechanisms that control regional differences in pigmentation, we have studied how a classical mouse mutation, droopy ear (de(H))
Externí odkaz:
https://doaj.org/article/59e25caeb7fc4226814679ffee5cbd9e
An essential component of precision medicine is the ability to predict an individual’s risk of disease based on genetic and non-genetic factors. For complex traits and diseases, assessing the risk due to genetic factors is challenging because it re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba103b6e7efb1ba3388b05933074763
https://europepmc.org/articles/PMC5630193/
https://europepmc.org/articles/PMC5630193/
Autor:
Hua Tang, Jennifer Li-Pook-Than, Dan Xie, Michael Snyder, Yoonha Choi, Linfeng Wu, Sophie I. Candille, Lihua Jiang
Publikováno v:
Nature
A large-scale analysis of variation in human protein levels between individuals is performed using mass-spectrometry-based proteomic technology, and a number of protein quantitative trait loci are identified; over 5% of proteins vary by more than 1.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bb8524ff71f29bf63ca7b1e6ab1dd9
https://doi.org/10.1038/nature12223
https://doi.org/10.1038/nature12223
Autor:
Gabriel A. Lazarin, James D. Goldberg, Kyle A. Beauchamp, Eric A. Evans, Sophie I. Candille, Imran S. Haque, Kenny K. Wong, K. Eerik Kaseniit, H. Peter Kang, Rebecca Mar-Heyming, Dale Muzzey, Nikita Mehta, Gregory J. Hogan, Kambiz Karimi
Publikováno v:
Genetics in Medicine
PurposeThe recent growth in pan-ethnic expanded carrier screening (ECS) has raised questions about how such panels might be designed and evaluated systematically. Design principles for ECS panels might improve clinical detection of at-risk couples an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b9b28baa25d3d9311139bfc4e3c088
https://doi.org/10.1101/080713
https://doi.org/10.1101/080713
Autor:
Ruth J. F. Loos, Ani W. Manichakul, Eric R. Gamazon, Kent D. Taylor, Craig L. Hanis, Esteban J. Parra, Adan Valladares-Salgado, Jerome I. Rotter, Hua Tang, Sophie I. Candille, Xin-Qun Wang, Miguel Cruz, Erwin P. Bottinger, Nancy J. Cox, Qing Duan, S. Krithika, Jesús Peralta-Romero, Yingchang Lu, Jason M. Torres, Jennifer E. Below, Andrew P. Morris, Stephen S. Rich, Yun Li, Omri Gottesman, Y.-D. Ida Chen
Publikováno v:
Scientific Reports
Scientific reports, vol 6, iss 1
Scientific reports, 6. Nature Publishing Group
Scientific reports, vol 6, iss 1
Scientific reports, 6. Nature Publishing Group
We performed genome-wide meta-analysis of lipid traits on three samples of Mexican and Mexican American ancestry comprising 4,383 individuals and followed up significant and highly suggestive associations in three additional Hispanic samples comprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327f82940b3eb44b2b702b612d9d51cd
http://europepmc.org/articles/PMC4726092
http://europepmc.org/articles/PMC4726092
Autor:
Claudia Greco, Elaine A. Ostrander, Hua Tang, Gregory S. Barsh, Douglas W. Smith, Tovi M. Anderson, Marco Musiani, Ettore Randi, Jennifer A. Leonard, Badri Padhukasahasram, Sophie I. Candille, Bridgett M. vonHoldt, Daniel R. Stahler, Robert K. Wayne, Carlos Bustamante
Publikováno v:
Science. 323:1339-1343
Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor ( Mc1r ) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b84abd7a307c38da718b50bf5f7af7
https://doi.org/10.1126/science.1165448
https://doi.org/10.1126/science.1165448
Autor:
Gregory S. Barsh, Rory J. Todhunter, Leigh Anne Clark, Sheila M. Schmutz, Julie A. Kerns, Michael Olivier, George Lust, Keith E. Murphy, Edward J. Cargill, Sophie I. Candille, T. G. Berryere
Publikováno v:
Genetics. 176:1679-1689
Mutations of pigment type switching have provided basic insight into melanocortin physiology and evolutionary adaptation. In all vertebrates that have been studied to date, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760ffb3854798b09b79e28b8c1f9161
https://doi.org/10.1534/genetics.107.074237
https://doi.org/10.1534/genetics.107.074237
Autor:
Damek V. Spacek, Carlos L. Araya, Can Cenik, Bilal Alsallakh, Emiliano P. Ricci, Michael Snyder, Hagen Tilgner, Hua Tang, Gun Woo Byeon, Elif Sarinay Cenik, Fabian Grubert, Sophie I. Candille
Publikováno v:
Genome Research
Genome Research, 2015, 25 (11), pp.1610-1621. ⟨10.1101/gr.193342.115⟩
Genome Research, 2015, 25 (11), pp.1610-1621. ⟨10.1101/gr.193342.115⟩
International audience; Elucidating the consequences of genetic differences between humans is essential for understanding phenotypic diversity and personalized medicine. Although variation in RNA levels, transcription factor binding, and chromatin ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551322ad80637e17ff08b8d65a45e08c
https://hal.science/hal-01911431
https://hal.science/hal-01911431