The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development

Autor: Arlette Hammann, Eric Solary, Oleg N. Demidov, Gaëtan Jego, Robinet E, A. Seignez, Sarah Richaud, Anastasia R. Goloudina, Evelyne Kohli, Magali Svrcek, Carmen Garrido, Eric Fourmaux, Deepti A, Anne-Laure Joly, Sophie Hébrard, Ada Collura, Elise Schmitt

Publikováno v: Oncogene
Oncogene, 2016, 35 (22), pp.2842-2851. ⟨10.1038/onc.2015.242⟩
Oncogene, Nature Publishing Group, 2016, 35 (22), pp.2842-2851. ⟨10.1038/onc.2015.242⟩
Oncogene, Nature Publishing Group, 2016, 35 (22), pp.2842-2851. 〈http://www.nature.com/onc/journal/v35/n22/full/onc2015242a.html〉. 〈10.1038/onc.2015.242〉

IF 7.932; International audience; Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c46f4dfc99d19a3da556ba4d180eca2
https://pubmed.ncbi.nlm.nih.gov/26364610

AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

Autor: Thomas E. Jensen, Jan Kopecky, Martin Rossmeisl, Ivan Mikšík, Simon A. Hawley, Marcin Baranowski, Pavel Flachs, Vladimir Kus, Petra Janovska, Zuzana Macek Jilkova, Benoit Viollet, Ondrej Kuda, Dasa Medrikova, Sophie Hébrard, Jan Górski, Tomas Jelenik, M Hensler

Publikováno v: Diabetes

OBJECTIVE The induction of obesity, dyslipidemia, and insulin resistance by high-fat diet in rodents can be prevented by n-3 long-chain polyunsaturated fatty acids (LC-PUFAs). We tested a hypothesis whether AMP-activated protein kinase (AMPK) has a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cb3b56af9371526dfc268b726bf308
http://europepmc.org/articles/PMC2963531

Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3

Autor: Anne-Laure Joly, Nadhir Yousfi, Manuel Rosa-Calatrava, Adonis Hazoumé, Sophie Hébrard, André Bouchot, Guillaume Wettstein, Olivier Terrier, Eric Solary, Gaëtan Jego, Laurent Cronier, Carmen Garrido, Martin E. Gleave, Dominique Thuringer

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(10)

The heat-shock protein 27 (HSP27) is up-regulated in tumor cells and released in their microenvironment. Here, we show that extracellular HSP27 has a proangiogenic effect evidenced on chick chorioallantoic membrane. To explore this effect, we test th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c78adb518cec84d647eb1f4b759e015
https://pubmed.ncbi.nlm.nih.gov/23804239

Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients

Autor: Magali Kitzmann, Marc Foretz, Sophie Hébrard, Céline Aguer, Jacques Mercier, Louise Lantier

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2011, 1812 (4), pp.423. ⟨10.1016/j.bbadis.2010.12.007⟩
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2011, 1812 (4), pp.423. 〈10.1016/j.bbadis.2010.12.007〉

International audience; Insulin resistance in type 2 diabetes (T2D) is associated with intramuscular lipid (IMCL) accumulation. To determine whether impaired lipid oxidation is involved in IMCL accumulation, we measured expression of genes involved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bd489f24c3732ef11f65235c5b59e1
https://hal.science/hal-00670745/document

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Autor: Elham Zarrinpashneh, Benoit Viollet, Jocelyne Leclerc, Marc Foretz, Kei Sakamoto, Maud Soty, Sophie Hébrard, Gilles Mithieux, Fabrizio Andreelli

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2010, 120 (7), pp.2355-69. ⟨10.1172/JCI40671⟩
Journal of Clinical Investigation, 2010, 120 (7), pp.2355-69. ⟨10.1172/JCI40671⟩

pages 1-15; International audience; Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d8060c30e5f3bd0d12200844d75bd2
https://www.hal.inserm.fr/inserm-00495746/file/Foretz_et_al.pdf