Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Sophie Goddard"'
1
Akademický článek
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic TumorigenesisSummary
Autor: Nicolas Chuvin, David F. Vincent, Roxane M. Pommier, Lindsay B. Alcaraz, Johann Gout, Cassandre Caligaris, Karam Yacoub, Victoire Cardot, Elodie Roger, Bastien Kaniewski, Sylvie Martel, Celia Cintas, Sophie Goddard-Léon, Amélie Colombe, Julie Valantin, Nicolas Gadot, Emilie Servoz, Jennifer Morton, Isabelle Goddard, Anne Couvelard, Vinciane Rebours, Julie Guillermet, Owen J. Sansom, Isabelle Treilleux, Ulrich Valcourt, Stéphanie Sentis, Pierre Dubus, Laurent Bartholin
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 2, Pp 263-282 (2017)
Background & Aims: Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ activates the canonical SMAD pathway through its interaction with th
Externí odkaz: https://doaj.org/article/e49cd12ee88d4e9a90e40577438a5e07
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2
Akademický článek
Activation of rapid oestrogen signalling in aggressive human breast cancers
Autor: Coralie Poulard, Isabelle Treilleux, Emilie Lavergne, Katia Bouchekioua‐Bouzaghou, Sophie Goddard‐Léon, Sylvie Chabaud, Olivier Trédan, Laura Corbo, Muriel Le Romancer
Publikováno v: EMBO Molecular Medicine, Vol 4, Iss 11, Pp 1200-1213 (2012)
Abstract Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ER
Externí odkaz: https://doaj.org/article/ae8551e708d64601b9e7786a96d4e4ce
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3
Akademický článek
ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice.
Autor: Anne Beghin, Stéphane Belin, Rouba Hage-Sleiman, Stéphanie Brunet Manquat, Sophie Goddard, Eric Tabone, Lars P Jordheim, Isabelle Treilleux, Marie-France Poupon, Jean-Jacques Diaz, Charles Dumontet
Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7478 (2009)
We have previously reported that ADP ribosylation factor like 2 (Arl2), a small GTPase, content influences microtubule dynamics and cell cycle distribution in breast tumor cells, as well as the degree and distribution of phosphorylated P53. Here we s
Externí odkaz: https://doaj.org/article/2e159abbf12f4af18f45bfe0c66c546d
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5
Akademický článek
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Autor: David F Vincent, Kai-Ping Yan, Isabelle Treilleux, Fabien Gay, Vanessa Arfi, Bastien Kaniewski, Julien C Marie, Florian Lepinasse, Sylvie Martel, Sophie Goddard-Leon, Juan L Iovanna, Pierre Dubus, Stéphane Garcia, Alain Puisieux, Ruth Rimokh, Nabeel Bardeesy, Jean-Yves Scoazec, Régine Losson, Laurent Bartholin
Publikováno v: PLoS Genetics, Vol 5, Iss 7, p e1000575 (2009)
Inactivation of the Transforming Growth Factor Beta (TGFbeta) tumor suppressor pathway contributes to the progression of Pancreatic Ductal AdenoCarcinoma (PDAC) since it is inactivated in virtually all cases of this malignancy. Genetic lesions inacti
Externí odkaz: https://doaj.org/article/cb97967f8e1a48baaf2fe656fecc984f
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