PDIA, an Iminosugar Compound with a Wide Biofilm Inhibitory Spectrum Covering Both Gram-Positive and Gram-Negative Human Bacterial Pathogens

Autor: Łucja Kozień, Estelle Gallienne, Olivier Martin, Sophie Front, Magdalena Strus, Piotr Heczko

Publikováno v: Microorganisms, Vol 10, Iss 6, p 1222 (2022)

Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobia

Externí odkaz: https://doaj.org/article/604854bb88dd41ec881cac6bfecd1c3d

Intramolecular Palladium-Catalyzed Carboamination for the Stereoselective Synthesis of Five-Membered Iminosugar C-Glycosides

Autor: Salia Tangara, Sophie Front, Olivier R. Martin, Estelle Gallienne

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, 2023, 88 (1), pp.86-96. ⟨10.1021/acs.joc.2c01866⟩

We report here a new method for the stereoselective synthesis of five-membered iminosugar C-glycosides using an intramolecular palladium-catalyzed carboamination. We have prepared efficiently two sugar-derived aminoalkenes, which were submitted to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52d1cf3312a7dfa8a91b76595398e78
https://hal.science/hal-04066875

4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations

Autor: Tim Wood, Sofia Almeida, Julie Charollais-Thoenig, Sophie Front, Estelle Gallienne, Céline Marmy, Vincent Pilloud, Olivier R. Martin, Vincent Zoete, Stéphane Demotz, Roger Marti

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2018, 26 (20), pp.5462-5469. ⟨10.1016/j.bmc.2018.09.023⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (20), pp.5462-5469. ⟨10.1016/j.bmc.2018.09.023⟩

International audience; (5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. We report herein an improved s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50af9c886c0e8bd662aae5364f47b51
https://univ-orleans.hal.science/hal-02179720

Stereoselective synthesis of 1-C-alkyl iminogalactitol derivatives, potential chaperones for galactosidase-linked LSDs: a real challenge

Autor: Anna Biela-Banaś, Estelle Gallienne, Olivier R. Martin, Sophie Front

Publikováno v: Tetrahedron Letters. 55:838-841

1-C-Alkyl iminogalactitol derivatives are highly desirable target compounds as potential pharmacological chaperones for the treatment of galactosidase-linked lysosomal storage disorders (LSDs). The synthesis of such compounds from d-galactose by a C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3044ec634fef44165fdda9912fda20e
https://doi.org/10.1016/j.tetlet.2013.12.024

N-Alkyl-, 1-C-Alkyl-, and 5-C-Alkyl-1,5-dideoxy-1,5-imino-(L)-ribitols as Galactosidase Inhibitors

Autor: Estelle Gallienne, Julie Charollais-Thoenig, Stéphane Demotz, Sophie Front, Olivier R. Martin

Publikováno v: ChemMedChem. 11(1)

A series of 1,5-dideoxy-1,5-imino-(l)-ribitol (DIR) derivatives carrying alkyl or functionalized alkyl groups were prepared and investigated as glycosidase inhibitors. These compounds were designed as simplified 4-epi-isofagomine (4-epi-IFG) mimics a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13aea321fd4b487dcb17e5af6dcb5b27
https://pubmed.ncbi.nlm.nih.gov/26644389