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Lentiviral standards to determine the sensitivity of assays that quantify lentiviral vector copy numbers and genomic insertion sites in cells

Autor: Guillaume Corre, Ababacar Seye, Sophie Frin, Maxime Ferrand, Kathrin Winkler, Cyril Luc, Fabien Dorange, Céline J. Rocca, Anne Galy

Publikováno v: Gene therapy. 29(9)

With an increasing number of gene therapy clinical trials and drugs reaching the market, it becomes important to standardize the methods that evaluate the efficacy and safety of gene therapy. We herein report the generation of lentiviral standards wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe4961126cf0a4d897ae8417bb36a6e
https://pubmed.ncbi.nlm.nih.gov/35194185

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Peptides derived from evolutionarily conserved domains in Beclin-1 and Beclin-2 enhance the entry of lentiviral vectors into human cells

Autor: Sophie Frin, Nathalie Chazal, Saliha Majdoul, Lucile Espert, Laurence Briant, David Fenard, Nathalie Holic, Jérémie Cosette, Anne Galy, Ababacar K. Seye, Eric Bernard

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2017, 292 (45), pp.18672-18681. ⟨10.1074/jbc.M117.800813⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (45), pp.18672-18681. ⟨10.1074/jbc.M117.800813⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (45), pp.18672-18681. 〈10.1074/jbc.M117.800813〉

International audience; Autophagy-related proteins such as Beclin-1 are involved in an array of complex processes, including antiviral responses, and may also modulate the efficiency of gene therapy viral vectors. The Tat-Beclin-1 (TB1) peptide has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74b042a3da89e46c17e2175b88a2f4
https://hal.science/hal-02147112/document

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Improvement of De Novo Cholesterol Biosynthesis Efficiently Promotes the Production of Human Immunodeficiency Virus Type 1-Derived Lentiviral Vectors

Autor: Ababacar K. Seye, Anne Galy, Sophie Frin, Nathalie Holic, David Fenard

Publikováno v: Hum Gene Ther Methods
Hum Gene Ther Methods, 2017, 28 (2), pp.67-77. ⟨10.1089/hgtb.2016.150⟩

International audience; The use of lentiviral vectors (LVs) for gene transfer in research, technological, or clinical applications requires the production of large amounts of vector. Mass production of clinical-grade LVs remains a challenge and limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed1a41de7bca6962f23146e5e17f944
https://hal.archives-ouvertes.fr/hal-02880986

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