Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sophie E.L. Chamberlain"'
Autor:
Jeremy Hall, Cezar M. Tigaret, Sophie E.L. Chamberlain, Michael C. Ashby, Joseph H.L.P. Sadowski, Jack R. Mellor
Publikováno v:
Tigaret, C M, Chamberlain, S E L, Sadowski, J H L, Hall, J, Ashby, M & Mellor, J 2018, ' Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus ', Journal of Neuroscience, vol. 38, no. 43, pp. 9252-9262 . https://doi.org/10.1523/JNEUROSCI.1160-18.2018
The Journal of Neuroscience
The Journal of Neuroscience
Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pat
Publikováno v:
Udakis, M, Pedrosa, V, Chamberlain, S E L, Clopath, C & Mellor, J R 2020, ' Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output ', Nature Communications, vol. 11, no. 1, 4395 (2020) . https://doi.org/10.1038/s41467-020-18074-8
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e17662c5a36c38d02ffcf4c789afe90
Autor:
Jonathan G. Hanley, Matthew Turvey, Nadia Jaafari, Gabrielle T. Parkinson, Jack R. Mellor, Sophie E.L. Chamberlain
Publikováno v:
Parkinson, G T, Chamberlain, S E L, Jaafari, N, Turvey, M R, Mellor, J & Hanley, J 2018, ' Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit ', Scientific Reports, vol. 8, no. 1, 4155 . https://doi.org/10.1038/s41598-018-22542-z
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
AMPA receptor (AMPAR) trafficking is a key determinant of synaptic strength and synaptic plasticity. Under basal conditions, constitutive trafficking maintains surface AMPARs by internalization into the endosomal system, where the majority are sorted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9323a739d6d9b7ee69091784f661ccc3
https://research-information.bris.ac.uk/ws/files/149568033/s41598_018_22542_z.pdf
https://research-information.bris.ac.uk/ws/files/149568033/s41598_018_22542_z.pdf
Autor:
Daniel L. Rocca, Philip Rubin, Sophie E.L. Chamberlain, Sriharsha Kantamneni, Kevin A. Wilkinson, Filip A. Konopacki, Jeremy M. Henley, Nadia Jaafari, Jack R. Mellor
Publikováno v:
Proceedings of the National Academy of Sciences
The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not been fully characterized. Smal
Autor:
Milos M. Petrovic, Jack R. Mellor, Katherine A. Buchanan, Neil V. Marrion, Sophie E.L. Chamberlain
Publikováno v:
Neuron
Summary Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor subtype involved and the critical intracellular signaling pathways engaged have remaine
Autor:
Sophie E.L. Chamberlain, Laura A. Atherton, Leonor M. Teles-Grilo Ruivo, Josef H.L.P. Sadowski, Jack R. Mellor
Kainate receptors (KARs) are ionotropic glutamate receptors that also activate noncanonical G-protein-coupled signaling pathways to depress the slow afterhyperpolarization (sAHP). Here we show that long-term depression of KAR-mediated synaptic transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945ac785676748b2209b8fd34ba493a7
https://europepmc.org/articles/PMC4223608/
https://europepmc.org/articles/PMC4223608/
Autor:
Jack R. Mellor, Inmaculada M. González-González, Sriharsha Kantamneni, Sophie E.L. Chamberlain, Kevin A. Wilkinson, Filip A. Konopacki, Jeremy M. Henley
Publikováno v:
Nature Neuroscience
Nature neuroscience
Nature neuroscience
Phosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. However, it is unknown whether phosphorylation and SUMOylation of GluK2 are important for activity-depend