Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sophie E. Acton"'
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein podoplanin (PDPN) on FRCs, inhibit
Externí odkaz:
https://doaj.org/article/ed468f6c1388465daedb3726df30ee90
Autor:
Jing Zhao, Sungwook Jung, Xiaofei Li, Lushen Li, Vivek Kasinath, Hengcheng Zhang, Said N. Movahedi, Ahmad Mardini, Gianmarco Sabiu, Yoonha Hwang, Vikas Saxena, Yang Song, Bing Ma, Sophie E. Acton, Pilhan Kim, Joren C. Madsen, Peter T. Sage, Stefan G. Tullius, George C. Tsokos, Jonathan S. Bromberg, Reza Abdi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transpla
Externí odkaz:
https://doaj.org/article/bc8427fba19b4be3b7fbe037cc02ca92
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The tumour microenvironment (TME) presents a major block to anti-tumour immune responses and to effective cancer immunotherapy. The inflammatory mediators such as cytokines, chemokines, growth factors and prostaglandins generated in the TME alter the
Externí odkaz:
https://doaj.org/article/e73fac2e64be48678ef36b2b4853e467
Autor:
Spyridon Makris, Charlotte M. de Winde, Harry L. Horsnell, Jesús A. Cantoral-Rebordinos, Rachel E. Finlay, Sophie E. Acton
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions wi
Externí odkaz:
https://doaj.org/article/67305cf3e9c7440783749926d16539cb
Autor:
Charlotte M. de Winde, Samantha L. George, Eva Crosas-Molist, Yukti Hari-Gupta, Abbey B. Arp, Agnesska C. Benjamin, Lindsey J. Millward, Spyridon Makris, Alexander Carver, Valerio Imperatore, Víctor G. Martínez, Victoria Sanz-Moreno, Sophie E. Acton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102976- (2021)
Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology
Externí odkaz:
https://doaj.org/article/4ccbb9bd840641f084f5a6f000008701
Autor:
Lukas Krasny, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Victor Garcia Martinez, Yi-Ru Yu, Sophie E. Acton, Ping-Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that permits quantification of up to
Externí odkaz:
https://doaj.org/article/b6c53000988f46049f04a777ee5ad346
Autor:
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2810-2822.e5 (2019)
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs under
Externí odkaz:
https://doaj.org/article/4fe1b76aeb144cf7aa575df20599c264
Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Autor:
Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Charlotte M. de Winde, Tanya Singh, Martina Jovancheva, Robin Kettler, Janos Kriston-Vizi, Sophie E. Acton
Lymph nodes are uniquely organised to form specialised niches for immune interactions. Fibroblastic reticular cells (FRCs) are an essential stromal component of lymph nodes – forming intricate 3-dimensional networks to facilitate communication betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a48e2281b22d866a7990356ce1562a
https://doi.org/10.1101/2022.12.01.518753
https://doi.org/10.1101/2022.12.01.518753
Publikováno v:
Medical Microbiology and Immunology
Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that act to bridge innate and adaptive immunity. DCs are critical in mounting effective immune responses to tissue damage, pathogens and cancer. Immature DCs continuousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72e7dfbf8d1aca601afd39c2df73143
http://europepmc.org/articles/PMC7395046
http://europepmc.org/articles/PMC7395046