Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sophie E Hussey"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132575 (2015)
AimsTo evaluate whether pharmacological TLR4 inhibition protects against acute and chronic fat-induced insulin resistance in rats.Materials and methodsFor the acute experiment, rats received a TLR4 inhibitor [TAK-242 or E5564 (2x5 mg/kg i.v. bolus)]
Externí odkaz:
https://doaj.org/article/7adf5d5e0f8c4e26b2ef79bf784a1127
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63983 (2013)
Accumulating evidence from animal studies suggest that chronic elevation of circulating intestinal-generated lipopolysaccharide (LPS) (i.e., metabolic endotoxemia) could play a role in the pathogenesis of insulin resistance. However, the effect of LP
Externí odkaz:
https://doaj.org/article/f9270458eda64a3fac07cea8e766018c
Publikováno v:
Biochemical and Biophysical Research Communications. 486:937-944
Individuals born small for gestational age (SGA) are at a higher risk of developing the metabolic syndrome later in life. IGF-1 resistance has been reported in placentae from SGA births and mutations in the Igf1 receptor gene have been reported in se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a95acd7165423899d916922cf94d289
https://doi.org/10.1016/j.bbrc.2017.03.129
https://doi.org/10.1016/j.bbrc.2017.03.129
Autor:
Jose De Jesus Garduño, Sophie E. Hussey, Joaquin Joya Galeana, Sumathy Mohan, Jinqi Li, Frank Zamarripa, Raweewan Lertwattanarak, Sangeeta Ghosh, Jack L. Lancaster, Nicolas Musi
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70:232-246
Aging is associated with alterations in glucose metabolism and sarcopenia that jointly contribute to a higher risk of developing type 2 diabetes. Because aging is considered as a state of low-grade inflammation, in this study we examined whether olde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabc3f8fa0f9dbe7c45097d72647eb4a
https://doi.org/10.1093/gerona/glu067
https://doi.org/10.1093/gerona/glu067
Autor:
Lawrence J. Mandarino, Benjamin P. Bowen, Andrew Garnham, Zhengping Yi, Carrie G Sharoff, Sophie E. Hussey, Mark Hargreaves
Publikováno v:
Medicine & Science in Sports & Exercise. 45:1069-1076
Endurance exercise training enhances the capacity of skeletal muscle to respond to insulin and to transport, oxidize, and store glucose as glycogen (6,17). In patients with type 2 diabetes (T2D), these adaptations may collectively act to lower blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000adf2025e8a440d4b9b08b81d6bf38
https://doi.org/10.1249/mss.0b013e3182814917
https://doi.org/10.1249/mss.0b013e3182814917
Publikováno v:
Diabetes, Obesity and Metabolism. 14:768-771
The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a705bec970ad51b1cdb48f449979e8ab
https://doi.org/10.1111/j.1463-1326.2012.01585.x
https://doi.org/10.1111/j.1463-1326.2012.01585.x
Autor:
Helen Lum, Luis Anaya, John J. Dubé, Andrea Alvarez, Yolanda Cipriani, Nicolas Musi, Sophie E. Hussey, José de Jesús Garduño-García
Insulin-sensitive tissues (muscle, liver) of individuals with obesity and type 2 diabetes mellitus are in a state of low-grade inflammation, characterised by increased Toll-like receptor (TLR) expression and TLR-driven signalling. However, the cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6d2b448dc1c8481fb7522bde1eb2d
https://europepmc.org/articles/PMC3945433/
https://europepmc.org/articles/PMC3945433/
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63983 (2013)
PLoS ONE
PLoS ONE
Accumulating evidence from animal studies suggest that chronic elevation of circulating intestinal-generated lipopolysaccharide (LPS) (i.e., metabolic endotoxemia) could play a role in the pathogenesis of insulin resistance. However, the effect of LP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229b22b9d18875998666e50a549f4dcf
http://europepmc.org/articles/PMC3660322?pdf=render
http://europepmc.org/articles/PMC3660322?pdf=render
Autor:
Sheila R. Costford, Sophie E. Hussey, Ralph A. DeFronzo, Brian Ely, Amira Klip, Nicolas Musi, Alicia Sanchez-Avila, Hanyu Liang
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 33, Iss 1, p e00004 (2012)
Bioscience Reports, Vol 33, Iss 1, p e00004 (2012)
Emerging evidence suggests that TLR (Toll-like receptor) 4 and downstream pathways [MAPKs (mitogen-activated protein kinases) and NF-κB (nuclear factor κB)] play an important role in the pathogenesis of insulin resistance. LPS (lipopolysaccharide)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1c1106899336db3c934ae49d8acec8
https://doi.org/10.1042/bsr20120098
https://doi.org/10.1042/bsr20120098
Autor:
Andrew Garnham, Sophie E. Hussey, Mark Hargreaves, Asker E. Jeukendrup, Sean L. McGee, John M. Wentworth
Publikováno v:
Diabetes, obesitymetabolism. 13(10)
We investigated the effects of exercise training on adipose tissue and skeletal muscle GLUT4 expression in patients with type 2 diabetes (T2D). Muscle and adipose tissue samples were obtained before and after 4-weeks of exercise training in seven pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed0c30bc261867924f4b5986617e425
https://pubmed.ncbi.nlm.nih.gov/21615668
https://pubmed.ncbi.nlm.nih.gov/21615668