Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Sophie Detienne"'
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Akademický článek
The cholinergic anti-inflammatory pathway delays TLR-induced skin allograft rejection in mice: cholinergic pathway modulates alloreactivity.
Autor: Claude Sadis, Sophie Detienne, Benoît Vokaer, Louis-Marie Charbonnier, Philippe Lemaître, Chloé Spilleboudt, Sandrine Delbauve, Carole Kubjak, Véronique Flamand, Kenneth A Field, Michel Goldman, Fleur S Benghiat, Alain Le Moine
Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79984 (2013)
Activation of innate immunity through Toll-like receptors (TLR) can abrogate transplantation tolerance by revealing hidden T cell alloreactivity. Separately, the cholinergic anti-inflammatory pathway has the capacity to dampen macrophage activation a
Externí odkaz: https://doaj.org/article/78cf1e163231466e87118c88cf7b9754
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2
Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties
Autor: Stanislas Goriely, Oberdan Leo, Séverine Thomas, Iain Welsby, Marjorie Vermeersch, Catherine Collignon, Viviana Lima Silva, Céline Molle, David Perez-Morga, Sophie Detienne, Romain Gineste, Arnaud M. Didierlaurent, Charlotte Givord, Assiya Assabban
Publikováno v: NPJ Vaccines, Vol. 3 (2018) P. 20
npj Vaccines, Vol 3, Iss 1, Pp 1-12 (2018)
NPJ vaccines, 3 (1
NPJ Vaccines
The oil-in-water emulsion Adjuvant System 03 (AS03) is one of the few adjuvants used in licensed vaccines. Previous work indicates that AS03 induces a local and transient inflammatory response that contributes to its adjuvant effect. However, the mol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7ccef06b7952682509feb37c0be5b6
https://doi.org/10.1038/s41541-018-0058-4
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3
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ gamma response promoting vaccine immunogenicity
Autor: Patricia Bourguignon, Catherine Collignon, Stanislas Goriely, Age K. Smilde, Sandra Morel, Bart N. Lambrecht, Caroline Hervé, Iain Welsby, Margherita Coccia, Mary J. van Helden, Arnaud M. Didierlaurent, Sophie Detienne, Robert A. van den Berg, Sheetij Dutta, Nathalie Garçon, Christopher J. Genito, Robbert van der Most, Aurélie Chalon, Katrijn Van Deun, David Franco, Norman C. Waters
Publikováno v: NPJ vaccines, 2
npj Vaccines, 2:25. Nature Publishing Group
NPJ VACCINES
npj Vaccines, Vol 2, Iss 1, Pp 1-14 (2017)
NPJ Vaccines
NPJ Vaccines, Vol. 2 (2017) P. 25
Expert Review of Vaccines, 2:25. Taylor and Francis Ltd.
Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4’-monophosphoryl lipid A (MPL), and a sapon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1741104b4913e94d587a82f9a497ef57
https://lirias.kuleuven.be/handle/123456789/620882
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4
Central Role of CD169(+) Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01
Autor: Sophie Delhaye, Catherine Collignon, Iain Welsby, Laurye Van Maele, Sophie Detienne, Abdelatif Elouahabi, Sandrine Wouters, Stanislas Goriely, Arnaud M. Didierlaurent, Maëlle Swertvaegher, Séverine Thomas, Aurélie Detavernier, Maria Elisabetta M.E. Coccia
Publikováno v: Scientific reports, 6
Scientific Reports
Saponins represent a promising class of vaccine adjuvant. Together with the TLR4-ligand MPL, QS-21 is part of the Adjuvant System AS01, a key component of the malaria and zoster candidate vaccines that display demonstrated clinical efficacy. However,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313424778a3881b351a96c03eac319e
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/242047
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5
Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
Autor: Stanislas Goriely, Pierre J. Courtoy, Abdelatif Elouahabi, Dominique De Wit, Séverine Thomas, Francisca N'Kuli, Romain Gineste, Arnaud M. Didierlaurent, Viviane Bechtold, Sophie Detienne, Iain Welsby, Sandrine Wouters, Thomas Reinheckel
Publikováno v: Frontiers in Immunology
Frontiers in immunology, 7
Frontiers in immunology, Vol. 7, p. 663 (2017)
Frontiers in Immunology, Vol. 7 (2017) P. 663
The adjuvant properties of the saponin QS-21 have been known for decades. It is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified anti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4953cb58cb5d916d140ed57369dcff5c
https://pubmed.ncbi.nlm.nih.gov/28105029
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6
Partial depletion of CD4+CD25+Foxp3+ T regulatory cells significantly increases morbidity during acute phase Toxoplasma gondii infection in resistant BALB/c mice
Autor: Stéphane De Craeye, Sushila D'Souza, Sophie Detienne, Vijay Morampudi, Michel Y Braun, Alain Le Moine
Publikováno v: Microbes and infection, 13
CD4+CD25+Foxp3+ T regulatory (Treg) cells, are known to regulate responses to infectious agents. Here we compared disease progression in BALB/c and C57BL/6(B6) mice infected perorally with Toxoplasma gondii for 7 days and examined the affect of parti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8221196117f3c86f64a7b0f166911f33
https://doi.org/10.1016/j.micinf.2011.01.006
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8
The Cholinergic Anti-Inflammatory Pathway Delays TLR-Induced Skin Allograft Rejection in Mice: Cholinergic Pathway Modulates Alloreactivity
Autor: Michel Goldman, Claude Sadis, Sophie Detienne, Sandrine Delbauve, Carole Kubjak, Fleur Samantha Benghiat, Philippe Lemaitre, Alain Le Moine, Louis-Marie Charbonnier, Benoît Vokaer, Chloé Spilleboudt, Véronique Flamand, Kenneth A. Field
Publikováno v: PLoS ONE
PloS one, 8 (11
PLoS ONE, Vol 8, Iss 11, p e79984 (2013)
Activation of innate immunity through Toll-like receptors (TLR) can abrogate transplantation tolerance by revealing hidden T cell alloreactivity. Separately, the cholinergic anti-inflammatory pathway has the capacity to dampen macrophage activation a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166d1a8d3047cead7abe83bdb2e310cb
http://europepmc.org/articles/PMC3836989
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9
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4
Autor: Ezra Aksoy, Wim Vanden Berghe, Michel Goldman, Zoulikha Amraoui, Katherine A. Fitzgerald, Guy Haegeman, Fabienne Willems, Sophie Detienne
Publikováno v: European journal of immunology. 35(7)
Phosphoinositide 3-kinases (PI3K) are known to regulate Toll-like receptor (TLR)-mediated inflammatory responses, but their impact on the different pathways of TLR signaling remains to be clarified. Here, we investigated the consequences of pharmacol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c13ba9384f09fc03b7781c75b01688
https://pubmed.ncbi.nlm.nih.gov/15940673
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10
Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression
Autor: Alain Le Moine, Luis Graca, Fleur Samantha Benghiat, Sophie Detienne, Michel Goldman, Fabrice Moore, Herman Waldmann, Véronique Flamand, Michel Y Braun, Sofia Buonocore
Publikováno v: Transplantation, 79 (6
BACKGROUND: Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their infl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbd4aa3b035c17602e1a04aee19acbb
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50334
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